42754-56-3

Basic information

• Product Name: Propanedinitrile, (methoxyphenylmethylene)-
• CAS NO: 42754-56-3
• Molecular Formula: C11H8N2O
• Molecular Weight: 184.197
• Mol File: 42754-56-3.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Propanedinitrile, (methoxyphenylmethylene)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedinitrile, (methoxyphenylmethylene)-(42754-56-3)
• EPA Substance Registry System: Propanedinitrile, (methoxyphenylmethylene)-(42754-56-3)

Safety Data

• Hazardous Substances Data: 42754-56-3(Hazardous Substances Data)

Upstream product

• 613-90-1 benzoyl cyanide 
• 5515-36-6 α-cyano-β-hydroxycinnamonitrile 
• 67-68-5 dimethyl sulfoxide 
• 616-42-2 dimethylsulfite 
• 46177-21-3 2-benzoylmalononitrile 
• 98-88-4 benzoyl chloride 
• 77-78-1 dimethyl sulfate 
• 109-77-3 malononitrile 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 4364-80-1 2-phenyl-1,1,2-tricyanoethylene 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 186581-53-3 diazomethane 

Downstream Products

• 81067-09-6 4-amino-6-phenyl-2-methoxypyrimidine-5-carbonitrile 
• 244233-71-4 1-(2-Nitrophenyl)-3-phenyl-5-aminopyrazole-4-carbonitrile 
• 42754-61-0 5-amino-3-phenyl-1H-pyrazole-4-carbonitrile 
• 476371-75-2 (2S,3R,4S,5R)-2-(4-amino-3-phenylpyrazolo[3,4-d]pyrimidin-1-yl)-5-hydroxymethyltetrahydrofuran-3,4-diol 
• 476371-71-8 1-((2S,3R,4S,5R)-3,4-dibenzoyl-5-benzoylmethyltetrahydrofuran-2-yl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine 
• 42754-69-8 4-Amino-3-phenylpyrazolo<3,4-d>pyrimidine 
• 587868-66-4 methyl 3-amino-4-cyano-5-phenyl-1-[3-(1,1,2,2-tetramethyl-1-silapropoxy)propyl]pyrrole-2-carboxylate 
• 58829-75-7 5-amino-1-methyl-3-phenyl-1H-pyrazole-4-carbonitrile 
• 1286278-41-8 5-amino-1-(2-hydroxyethyl)-3-phenyl-1H-pyrazole-4-carbonitrile 
• 1286278-42-9 C₁₃H₁₃N₅O 
• 1286278-43-0 C₁₄H₁₅N₅O₃S 
• 1286278-44-1 1-(2-azidoethyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1286278-48-5 1-(2-(4-butyl-1H-1,2,3-triazol-1-yl)ethyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1286278-49-6 1-(2-(4-hexyl-1H-1,2,3-triazol-1-yl)ethyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 

Relevant articles and documents

Synthesis of 2,5,7-triaryl-4,7(6,7)-dihydropyrazolo[1,5-a]pyrimidine-3- carbonitriles by reaction of 5(3)-amino-3(5)-aryl-1H-pyrazole-4-carbonitriles with chalcones

The reaction of 5(3)-amino-3(5)-aryl-1H-pyrazole-4-carbonitriles with 1,3-diaryl-2-propen-1-ones (chalcones) in refluxing DMF leads to 2,5,7-triaryl-4,7(6,7)-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitriles. In DMSO solution, the latter exist in equilibri

Simple access to highly functional bicyclic γ- and δ-lactams: Origins of chirality transfer to contiguous tertiary/quaternary stereocenters assessed by DFT

This paper describes the synthesis of both polysubstituted oxazolo-pyrrolidinones and -piperidinones by a domino process. The methodology is based on the reaction between hydroxyl halogenoamides and Michael acceptors, which leads efficiently to bicyclic lactams. The process is compatible with unsymmetrical electron-withdrawing groups on the Michael acceptor, which allows the formation of two contiguous and fully controlled tertiary and quaternary stereocenters. In the case of tetrasubstituted Michael acceptors, two adjacent quaternary stereocenters are formed in good yield. Starting from (R)-phenylglycinol derived amides results in the formation of enantioenriched bicyclic lactams in low to good yields and with high levels of stereo-selectivity, thus greatly increasing the scope and interest of this strategy. The origins of chirality transfer and diastereoselectivity were studied by DFT calculations and have been attributed to a kinetic control in one of the last two steps of the reaction sequence. This selectivity is dependent upon both the substituents on the Michael acceptor and the sodium cation chelation.

1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D

Phospholipase D enzymes cleave lipid substrates to produce phosphatidic acid, an important precursor for many essential cellular molecules. Phospholipase D is a target to modulate cancer-cell invasiveness. This study reports synthesis of a new class of phospholipase D inhibitors based on 1,3-disubstituted-4-amino-pyrazolopyrimidine core structure. These molecules were synthesized and used to perform initial screening for the inhibition of purified bacterial phospholipase D, which is highly homologous to the human PLD1. Initially tested with the bacterial phospholipase D enzyme, then confirmed with the recombinant human PLD1 and PLD2 enzymes, the molecules presented here exhibited inhibition of phospholipase D activity (IC50) in the low-nanomolar to low-micromolar range with both monomeric substrate diC4PC and phospholipid vesicles and micelles. The data strongly indicate that these inhibitory molecules directly block enzyme/vesicle substrate binding. Preliminary activity studies using recombinant human phospholipase Ds in in vivo cell assays measuring both transphosphatidylation and head-group cleavage indicate inhibition in the mid- to low-nanomolar range for these potent inhibitory novel molecules in a physiological environment. This study reports synthesis of a new class of PLD inhibitors based on 1,3-disubstituted-4-amino-pyrazolopyrimidine core structure. These molecules exhibited inhibition of human recombinant PLD activity (IC 50) in the low-nanomolar to low-micromolar range with monomeric substrate diC4PC and phospholipid vesicles and micelles. Preliminary activity studies using recombinant human PLDs in in vivo cell assays measuring both transphosphatidylation and head-group cleavage indicates inhibition in the mid- to low-nanomolar range for these potent inhibitory novel molecules in a physiological environment.