N²-(1-ethyl-propyl)-5-(2-methoxy-4-trifluoromethoxy-phenyl)-6-methyl-pyrazine-2,3-diamine

Base Information

• Chemical Name: N²-(1-ethyl-propyl)-5-(2-methoxy-4-trifluoromethoxy-phenyl)-6-methyl-pyrazine-2,3-diamine
• CAS No.: 666254-69-9
• Molecular Formula: C₁₈H₂₃F₃N₄O₂
• Molecular Weight: 384.401

Synonyms:N²-(1-ethyl-propyl)-5-(2-methoxy-4-trifluoromethoxy-phenyl)-6-methyl-pyrazine-2,3-diamine

Chemical Property of N²-(1-ethyl-propyl)-5-(2-methoxy-4-trifluoromethoxy-phenyl)-6-methyl-pyrazine-2,3-diamine

Chemical Property:

Purity/Quality:

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Technology Process of N²-(1-ethyl-propyl)-5-(2-methoxy-4-trifluoromethoxy-phenyl)-6-methyl-pyrazine-2,3-diamine

There total 10 articles about N²-(1-ethyl-propyl)-5-(2-methoxy-4-trifluoromethoxy-phenyl)-6-methyl-pyrazine-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-4-trifluoromethoxybenzeneboronic acid (355836-10-1) + 5-bromo-N2-(1-ethyl-propyl)-6-methyl-pyrazine-2,3-diamine (870689-48-8) → N2-(1-ethyl-propyl)-5-(2-methoxy-4-trifluoromethoxy-phenyl)-6-methyl-pyrazine-2,3-diamine (666254-69-9)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 80 ℃; for 16h;

Reference yield:

6-chloro-[N-(1-ethyl)propyl]pyrazine-2-amine (355836-15-6) → N2-(1-ethyl-propyl)-5-(2-methoxy-4-trifluoromethoxy-phenyl)-6-methyl-pyrazine-2,3-diamine (666254-69-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) / tetrahydrofuran / 0.17 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: N-Bromosuccinimide / chloroform / 1 h / 0 - 20 °C

3.1: ammonia / copper / ethanol / 16 h / 20 - 100 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 16 h / 80 °C

With N-Bromosuccinimide; ammonia; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); copper; In tetrahydrofuran; ethanol; chloroform; water; toluene; 4.1: Suzuki Coupling;

Reference yield:

N-(1-ethyl)propyl-6-methylpyrazine-2-amine (355836-17-8) → N2-(1-ethyl-propyl)-5-(2-methoxy-4-trifluoromethoxy-phenyl)-6-methyl-pyrazine-2,3-diamine (666254-69-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / chloroform / 1 h / 0 - 20 °C

2: ammonia / copper / ethanol / 16 h / 20 - 100 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 16 h / 80 °C

With N-Bromosuccinimide; ammonia; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper; In ethanol; chloroform; water; toluene; 3: Suzuki Coupling;

upstream raw materials:

2-methoxy-4-trifluoromethoxybenzeneboronic acid

5-bromo-N²-(1-ethyl-propyl)-6-methyl-pyrazine-2,3-diamine

6-chloro-[N-(1-ethyl)propyl]pyrazine-2-amine

N-(1-ethyl)propyl-6-methylpyrazine-2-amine

Downstream raw materials:

N-[3-(1-ethyl-propylamino)-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyrazin-2-yl]-acetamide

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