(+/-)-(1-hydroxy-3-phenylpropyl)(methoxymethoxy)methane-1,1-dicarbonitrile

Base Information

• Chemical Name: (+/-)-(1-hydroxy-3-phenylpropyl)(methoxymethoxy)methane-1,1-dicarbonitrile
• CAS No.: 268551-15-1
• Molecular Formula: C₁₄H₁₆N₂O₃
• Molecular Weight: 260.293
• Mol file: 268551-15-1.mol

Synonyms:(+/-)-(1-hydroxy-3-phenylpropyl)(methoxymethoxy)methane-1,1-dicarbonitrile

Chemical Property of (+/-)-(1-hydroxy-3-phenylpropyl)(methoxymethoxy)methane-1,1-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (+/-)-(1-hydroxy-3-phenylpropyl)(methoxymethoxy)methane-1,1-dicarbonitrile

There total 1 articles about (+/-)-(1-hydroxy-3-phenylpropyl)(methoxymethoxy)methane-1,1-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-phenyl-propionaldehyde (104-53-0) + (methoxymethoxy)methane-1,1-dicarbonitrile → (+/-)-(1-hydroxy-3-phenylpropyl)(methoxymethoxy)methane-1,1-dicarbonitrile (268551-15-1)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(00)00040-5

Reference yield:

(+/-)-(1-hydroxy-3-phenylpropyl)(methoxymethoxy)methane-1,1-dicarbonitrile (268551-15-1) → 2-(1-azido-3-phenyl-propyl)-2-hydroxy-malononitrile

Guidance literature:

Multi-step reaction with 3 steps

1: 127.2 mg / CH₂Cl₂ / 0.5 h / 0 °C

2: 90 percent / NaN₃ / dimethylformamide / 0.17 h / 0 °C

3: TFA; H₂O / tetrahydrofuran / 24 h / 20 °C

With sodium azide; water; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: sulfonylation / 2: Substitution / 3: Hydrolysis;

DOI:10.1016/S0040-4020(00)00040-5

Reference yield:

(+/-)-(1-hydroxy-3-phenylpropyl)(methoxymethoxy)methane-1,1-dicarbonitrile (268551-15-1) → (+/-)-2-azido-N-butyl-4-phenylbutanamide

Guidance literature:

Multi-step reaction with 4 steps

1: 127.2 mg / CH₂Cl₂ / 0.5 h / 0 °C

2: 90 percent / NaN₃ / dimethylformamide / 0.17 h / 0 °C

3: TFA; H₂O / tetrahydrofuran / 24 h / 20 °C

4: 200 mg / CH₂Cl₂ / 0.25 h / 20 °C

With sodium azide; water; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: sulfonylation / 2: Substitution / 3: Hydrolysis / 4: Acylation;

DOI:10.1016/S0040-4020(00)00040-5

upstream raw materials:

3-phenyl-propionaldehyde

Downstream raw materials:

(+/-)-1-[dicyano(methoxymethoxy)methyl]-3-phenylpropyl(trifluoromethyl)-sulfonate

(+/-)-(1-azido-3-phenylpropyl)(methoxymethoxy)methane-1,1-dicarbonitrile