N-{2-[1-(2-ethanesulfonylamino-phenyl)-cyclohexa-2,5-dienyl]ethyl}acrylamide

Base Information

• Chemical Name: N-{2-[1-(2-ethanesulfonylamino-phenyl)-cyclohexa-2,5-dienyl]ethyl}acrylamide
• CAS No.: 955116-96-8
• Molecular Formula: C₁₉H₂₄N₂O₃S
• Molecular Weight: 360.477
• Mol file: 955116-96-8.mol

Synonyms:N-{2-[1-(2-ethanesulfonylamino-phenyl)-cyclohexa-2,5-dienyl]ethyl}acrylamide

Chemical Property of N-{2-[1-(2-ethanesulfonylamino-phenyl)-cyclohexa-2,5-dienyl]ethyl}acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{2-[1-(2-ethanesulfonylamino-phenyl)-cyclohexa-2,5-dienyl]ethyl}acrylamide

There total 4 articles about N-{2-[1-(2-ethanesulfonylamino-phenyl)-cyclohexa-2,5-dienyl]ethyl}acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanesulfonic acid {2-[1-(2-aminoethyl)-cyclohexa-2,5-dienyl]phenyl}amide (955116-98-0) + acryloyl chloride (814-68-6,25189-84-8) → N-{2-[1-(2-ethanesulfonylamino-phenyl)-cyclohexa-2,5-dienyl]ethyl}acrylamide (955116-96-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ol701493k

Reference yield:

ethanesulfonic acid biphenyl-2-ylamide (57638-94-5) → N-{2-[1-(2-ethanesulfonylamino-phenyl)-cyclohexa-2,5-dienyl]ethyl}acrylamide (955116-96-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: Li; NH₃ / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.3: 70 percent / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.1: LiAlH₄; AlCl₃ / tetrahydrofuran / 4 h / 20 °C

3.1: 0.095 g / Et₃N / CH₂Cl₂ / 12 h / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; aluminium trichloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/ol701493k

Reference yield:

ethanesulfonic acid [2-(1-cyanomethyl-cyclohexa-2,5-dienyl)phenyl]carbamic amide (955116-90-2) → N-{2-[1-(2-ethanesulfonylamino-phenyl)-cyclohexa-2,5-dienyl]ethyl}acrylamide (955116-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄; AlCl₃ / tetrahydrofuran / 4 h / 20 °C

2: 0.095 g / Et₃N / CH₂Cl₂ / 12 h / 20 °C

With lithium aluminium tetrahydride; aluminium trichloride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol701493k

upstream raw materials:

ethanesulfonic acid {2-[1-(2-aminoethyl)-cyclohexa-2,5-dienyl]phenyl}amide

acryloyl chloride

ethanesulfonic acid biphenyl-2-ylamide

ethanesulfonic acid [2-(1-cyanomethyl-cyclohexa-2,5-dienyl)phenyl]carbamic amide