N-(2-methoxyethyl)-N-[(Z)-{[(1R,3R)-3-(4-methoxyphenyl)cyclopentyl]oxy}-NNO-azoxy]-2-methylpropane-2-amine

Base Information

Chemical Name:N-(2-methoxyethyl)-N-[(Z)-{[(1R,3R)-3-(4-methoxyphenyl)cyclopentyl]oxy}-NNO-azoxy]-2-methylpropane-2-amine
CAS No.:1325231-62-6
Molecular Formula:C₁₉H₃₁N₃O₄
Molecular Weight:365.473
Hs Code.:

Synonyms:N-(2-methoxyethyl)-N-[(Z)-{[(1R,3R)-3-(4-methoxyphenyl)cyclopentyl]oxy}-NNO-azoxy]-2-methylpropane-2-amine

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Chemical Property of N-(2-methoxyethyl)-N-[(Z)-{[(1R,3R)-3-(4-methoxyphenyl)cyclopentyl]oxy}-NNO-azoxy]-2-methylpropane-2-amine

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Technology Process of N-(2-methoxyethyl)-N-[(Z)-{[(1R,3R)-3-(4-methoxyphenyl)cyclopentyl]oxy}-NNO-azoxy]-2-methylpropane-2-amine

There total 5 articles about N-(2-methoxyethyl)-N-[(Z)-{[(1R,3R)-3-(4-methoxyphenyl)cyclopentyl]oxy}-NNO-azoxy]-2-methylpropane-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1325231-61-5
2-{tert-butyl[(Z)-{[(1R,3R)-3-(4-methoxyphenyl)cyclopentyl]oxy}-NNO-azoxy]amino}ethanol

: 74-88-4
methyl iodide

: 1325231-62-6
N-(2-methoxyethyl)-N-[(Z)-{[(1R,3R)-3-(4-methoxyphenyl)cyclopentyl]oxy}-NNO-azoxy]-2-methylpropane-2-amine

Guidance literature:: 2-{tert-butyl[(Z)-{[(1R,3R)-3-(4-methoxyphenyl)cyclopentyl]oxy}-NNO-azoxy]amino}ethanol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 930-30-3
cyclopent-2-enone

: 1325231-62-6
N-(2-methoxyethyl)-N-[(Z)-{[(1R,3R)-3-(4-methoxyphenyl)cyclopentyl]oxy}-NNO-azoxy]-2-methylpropane-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / 1,4-dioxane / 100 °C

2.1: sodium formate; NAD; formate hydrogenase 101; ketoreductase NAD dependent 102 / 30 °C / pH 6.5 / Aqueous phosphate buffer; Enzymatic reaction

3.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

4.1: dimethyl sulfoxide / 16 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

5.2: 0 - 20 °C

With dmap; formate hydrogenase 101; ketoreductase NAD dependent 102; NAD; water; sodium formate; sodium hydride; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 155325-51-2
(R)-3-(4-methoxyphenyl)cyclopentan-1-one

: 1325231-62-6
N-(2-methoxyethyl)-N-[(Z)-{[(1R,3R)-3-(4-methoxyphenyl)cyclopentyl]oxy}-NNO-azoxy]-2-methylpropane-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium formate; NAD; formate hydrogenase 101; ketoreductase NAD dependent 102 / 30 °C / pH 6.5 / Aqueous phosphate buffer; Enzymatic reaction

2.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

3.1: dimethyl sulfoxide / 16 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

4.2: 0 - 20 °C

With dmap; formate hydrogenase 101; ketoreductase NAD dependent 102; NAD; sodium formate; sodium hydride; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;