(2S,3R,4S)-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethyl-3-[(triethylsilyl)oxy]pentanamide

Base Information

Chemical Name:(2S,3R,4S)-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethyl-3-[(triethylsilyl)oxy]pentanamide
CAS No.:857847-25-7
Molecular Formula:C₂₃H₄₁NO₅Si
Molecular Weight:439.668
Hs Code.:

Synonyms:(2S,3R,4S)-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethyl-3-[(triethylsilyl)oxy]pentanamide

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Chemical Property of (2S,3R,4S)-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethyl-3-[(triethylsilyl)oxy]pentanamide

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Technology Process of (2S,3R,4S)-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethyl-3-[(triethylsilyl)oxy]pentanamide

There total 2 articles about (2S,3R,4S)-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethyl-3-[(triethylsilyl)oxy]pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 857847-11-1
(2S,3R,4S)-3-hydroxy-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 857847-25-7
(2S,3R,4S)-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethyl-3-[(triethylsilyl)oxy]pentanamide

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1055/s-2005-865302

Reference yield:

: 812649-71-1
(S)-4-benzyl-3-{(2S,3R,4S)-3-hydroxy-5-[(4-methoxybenzyl)oxy]-2,4-dimethylpentanoyl}oxazolidin-2-one

: 857847-25-7
(2S,3R,4S)-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethyl-3-[(triethylsilyl)oxy]pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Me₃Al / CH₂Cl₂; heptane / 1 h / 20 °C

1.2: 99 percent / CH₂Cl₂; heptane / -20 - 20 °C

2.1: 85 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

With 2,6-dimethylpyridine; trimethylaluminum; In n-heptane; dichloromethane;
DOI:10.1055/s-2005-865302