(2S,3R,4S)-3-hydroxy-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

Base Information

Chemical Name:(2S,3R,4S)-3-hydroxy-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide
CAS No.:857847-11-1
Molecular Formula:C₁₇H₂₇NO₅
Molecular Weight:325.405
Hs Code.:

Synonyms:(2S,3R,4S)-3-hydroxy-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

Suppliers and Price of (2S,3R,4S)-3-hydroxy-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R,4S)-3-hydroxy-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R,4S)-3-hydroxy-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

There total 1 articles about (2S,3R,4S)-3-hydroxy-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 812649-71-1
(S)-4-benzyl-3-{(2S,3R,4S)-3-hydroxy-5-[(4-methoxybenzyl)oxy]-2,4-dimethylpentanoyl}oxazolidin-2-one

: 857847-11-1
(2S,3R,4S)-3-hydroxy-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

Guidance literature:: N,O-dimethylhydroxylamine*hydrochloride; With trimethylaluminum; In n-heptane; dichloromethane; at 20 ℃; for 1h;

(S)-4-benzyl-3-{(2S,3R,4S)-3-hydroxy-5-[(4-methoxybenzyl)oxy]-2,4-dimethylpentanoyl}oxazolidin-2-one; In n-heptane; dichloromethane; at -20 - 20 ℃;
DOI:10.1055/s-2005-865302

Reference yield: 85.0%

: 857847-11-1
(2S,3R,4S)-3-hydroxy-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 857847-25-7
(2S,3R,4S)-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethyl-3-[(triethylsilyl)oxy]pentanamide

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1055/s-2005-865302

Reference yield:

: 857847-11-1
(2S,3R,4S)-3-hydroxy-N-methoxy-5-[(4-methoxybenzyl)oxy]-N,2,4-trimethylpentanamide

: 857847-12-2
(2S,3R,4S)-5-[(4-methoxybenzyl)oxy]-2,4-dimethyl-3-[(triethylsilyl)oxy]pentanal

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

2: 86 percent / DIBAL-H / tetrahydrofuran; heptane / 0.25 h / -78 °C

With 2,6-dimethylpyridine; diisobutylaluminium hydride; In tetrahydrofuran; n-heptane; dichloromethane;
DOI:10.1055/s-2005-865302