N-<(4-hydroxyphenyl)acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline

Base Information

Chemical Name:N-<(4-hydroxyphenyl)acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline
CAS No.:224577-18-8
Molecular Formula:C₃₇H₄₅N₃O₈
Molecular Weight:659.78
Hs Code.:

Synonyms:N-<(4-hydroxyphenyl)acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<(4-hydroxyphenyl)acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline

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Technology Process of N-<(4-hydroxyphenyl)acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline

There total 7 articles about N-<(4-hydroxyphenyl)acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 156-38-7
4-hydroxyphenylacetate

: L-leucyl-L-(α-O-benzylaspartyl)-L-valine benzyl ester hydrochloride

: 224577-18-8
N-<(4-hydroxyphenyl)acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; for 14h;
DOI:10.1021/jm980673g

Reference yield:

: 3392-09-4
Boc-Leu-ONSu

: 224577-18-8
N-<(4-hydroxyphenyl)acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: 92 percent / 4 M HCl / dioxane / 2 h / Ambient temperature

3: 66 percent / HOBt, EDC, Et₃N / dimethylformamide / 14 h

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980673g

Reference yield:

: 13798-75-9
N^α-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester

: 224577-18-8
N-<(4-hydroxyphenyl)acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: 4 M HCl / dioxane / 2 h / Ambient temperature

3: 86 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 92 percent / 4 M HCl / dioxane / 2 h / Ambient temperature

5: 66 percent / HOBt, EDC, Et₃N / dimethylformamide / 14 h

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980673g