benzyl 10-benzyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

Base Information

Chemical Name:benzyl 10-benzyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate
CAS No.:1596117-32-6
Molecular Formula:C₂₈H₂₁NO₃S
Molecular Weight:451.546
Hs Code.:

Synonyms:benzyl 10-benzyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

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Chemical Property of benzyl 10-benzyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

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Technology Process of benzyl 10-benzyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

There total 6 articles about benzyl 10-benzyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 440627-14-5
11-oxo-10,11-dihydro-dibenzo [b,f][1,4]thiazepine-8-carboxylic acid

: 100-39-0
benzyl bromide

: 1596117-32-6
benzyl 10-benzyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

Guidance literature:: 11-oxo-10,11-dihydro-dibenzo [b,f][1,4]thiazepine-8-carboxylic acid; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;
DOI:10.1021/jm500126s

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1596117-32-6
benzyl 10-benzyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 - 40 °C

2.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 60 °C

3.1: platinum(IV) oxide; palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0 - 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

5.2: 1.5 h / 20 °C

With platinum(IV) oxide; palladium 10% on activated carbon; hydrogen; sodium hydride; caesium carbonate; 1,1'-carbonyldiimidazole; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500126s

Reference yield:

: 1319194-13-2
methyl 4-((2-(methoxycarbonyl) phenyl) thio)-3-nitrobenzoate

: 1596117-32-6
benzyl 10-benzyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 60 °C

2.1: platinum(IV) oxide; palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

4.2: 1.5 h / 20 °C

With platinum(IV) oxide; palladium 10% on activated carbon; hydrogen; sodium hydride; 1,1'-carbonyldiimidazole; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500126s