(S)-2-(((R)-2-(2-(3-(((benzyloxy)carbonyl)amino)propyl)phenoxy)-propyl)(tert-butoxycarbonyl)amino)-2-cyclopropylacetic acid

Base Information

Chemical Name:(S)-2-(((R)-2-(2-(3-(((benzyloxy)carbonyl)amino)propyl)phenoxy)-propyl)(tert-butoxycarbonyl)amino)-2-cyclopropylacetic acid
CAS No.:874336-36-4
Molecular Formula:C₃₀H₄₀N₂O₇
Molecular Weight:540.657
Hs Code.:

Synonyms:(S)-2-(((R)-2-(2-(3-(((benzyloxy)carbonyl)amino)propyl)phenoxy)-propyl)(tert-butoxycarbonyl)amino)-2-cyclopropylacetic acid

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Chemical Property of (S)-2-(((R)-2-(2-(3-(((benzyloxy)carbonyl)amino)propyl)phenoxy)-propyl)(tert-butoxycarbonyl)amino)-2-cyclopropylacetic acid

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Technology Process of (S)-2-(((R)-2-(2-(3-(((benzyloxy)carbonyl)amino)propyl)phenoxy)-propyl)(tert-butoxycarbonyl)amino)-2-cyclopropylacetic acid

There total 8 articles about (S)-2-(((R)-2-(2-(3-(((benzyloxy)carbonyl)amino)propyl)phenoxy)-propyl)(tert-butoxycarbonyl)amino)-2-cyclopropylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 49606-99-7,5687-71-8,15785-26-9,49607-01-4
(S)-2-amino-2-cyclopropylacetic acid

: 874336-36-4
(S)-2-(((R)-2-(2-(3-(((benzyloxy)carbonyl)amino)propyl)phenoxy)-propyl)(tert-butoxycarbonyl)amino)-2-cyclopropylacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 0 - 20 °C / Inert atmosphere

2: sodium carbonate / water / 20 °C / Inert atmosphere

3: sodium carbonate; potassium iodide / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

4: sodium carbonate / tetrahydrofuran; water / 24 h / 20 °C / Inert atmosphere

5: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; sodium carbonate; potassium iodide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm2007062

Reference yield:

: 874336-35-3
C₃₁H₄₂N₂O₇

: 874336-36-4
(S)-2-(((R)-2-(2-(3-(((benzyloxy)carbonyl)amino)propyl)phenoxy)-propyl)(tert-butoxycarbonyl)amino)-2-cyclopropylacetic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm2007062

Reference yield:

: 874336-15-9
C₂₀H₂₅NO₄

: 874336-36-4
(S)-2-(((R)-2-(2-(3-(((benzyloxy)carbonyl)amino)propyl)phenoxy)-propyl)(tert-butoxycarbonyl)amino)-2-cyclopropylacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 20 °C / Inert atmosphere

2: sodium carbonate; potassium iodide / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

3: sodium carbonate / tetrahydrofuran; water / 24 h / 20 °C / Inert atmosphere

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

With N-Bromosuccinimide; lithium hydroxide monohydrate; sodium carbonate; triphenylphosphine; potassium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm2007062