S-Cyclopropylglycine Methyl ester hydrochloride

Base Information

• Chemical Name: S-Cyclopropylglycine Methyl ester hydrochloride
• CAS No.: 138326-68-8
• Molecular Formula: C6H11NO2.ClH
• Molecular Weight: 165.62
• Hs Code.: 2922498590
• Mol file: 138326-68-8.mol

Synonyms:S-Cyclopropylglycine Methyl ester hydrochloride;L-Cyclopropylglycine methyl ester hydrochloride;Methyl (S)-a-amino-cyclopropaneacetate HCl;(S)-Methyl 2-amino-2-cyclopropylacetate hydrochloride

Chemical Property of S-Cyclopropylglycine Methyl ester hydrochloride

Chemical Property:

• PSA: 52.32000
• LogP: 1.39900
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl(2S)-amino(cyclopropyl)-acetatehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-Cyclopropylglycine Methyl ester hydrochloride

There total 4 articles about S-Cyclopropylglycine Methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,2-dimethoxy-propane (77-76-9) + (2S)-2-[[(tert-butoxy)carbonyl]amino]-2-cyclopropylacetic acid (155976-13-9) → (S)methyl 2-amino-2-cyclopropylacetate hydrochloride (138326-68-8)

Guidance literature:

With hydrogenchloride; In water; at 40 ℃;

Reference yield: 62.0%

methanol (67-56-1) + (S)-2-amino-2-cyclopropylacetic acid (49606-99-7,5687-71-8,15785-26-9,49607-01-4) → (S)methyl 2-amino-2-cyclopropylacetate hydrochloride (138326-68-8)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 4h; Heating / reflux;

Reference yield:

(S)-2-amino-2-cyclopropylacetic acid (49606-99-7,5687-71-8,15785-26-9,49607-01-4) + acetyl chloride (75-36-5) → (S)methyl 2-amino-2-cyclopropylacetate hydrochloride (138326-68-8)

Guidance literature:

In methanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm2007062

upstream raw materials:

methanol

(S)-2-amino-2-cyclopropylacetic acid

2,2-dimethoxy-propane

(2S)-2-[[(tert-butoxy)carbonyl]amino]-2-cyclopropylacetic acid

Downstream raw materials:

(S)-cyclopropyl-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)acetic acid methyl ester

C₂₆H₃₃FN₂O₅

C₂₆H₃₄N₂O₅

(S)-2-(((R)-2-(2-(3-(((benzyloxy)carbonyl)amino)propyl)phenoxy)-propyl)(tert-butoxycarbonyl)amino)-2-cyclopropylacetic acid