2-{[2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid

Base Information

Chemical Name:2-{[2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid
CAS No.:869796-50-9
Molecular Formula:C₂₈H₂₅N₇O₃
Molecular Weight:507.552
Hs Code.:

Synonyms:2-{[2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid

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Chemical Property of 2-{[2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-{[2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid

There total 7 articles about 2-{[2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 673488-58-9
(S)-2-{[2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid methyl ester

: 869796-50-9
2-{[2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid

Guidance literature:: (S)-2-{[2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid methyl ester; With methanol; sodium hydroxide; water; at 22 ℃; for 12h;

With sodium dihydrogenphosphate; In water; at 40 ℃; under 0.750075 Torr; pH=5;

Reference yield: 100.0%

: 2-{[(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid methyl ester

: 869796-50-9
2-{[2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid

Guidance literature:: 2-{[(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid methyl ester; With methanol; sodium hydroxide; water; at 20 ℃; for 12h;

With sodium dihydrogenphosphate; water;

Reference yield:

: 673488-57-8
(3-(N-phenyl-N-pyridin-2-yl)-amino)-2-(di-tert-butoxycarbonyl)-amino-propionic acid methyl ester

: 869796-50-9
2-{[2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carbonyl]-amino}-3-(phenyl-pyridin-2-yl-amino)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: Resolution of racemate

2.1: hydrogenchloride / 1,4-dioxane / 12 h / 0 - 22 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 13.5 h / 0 - 22 °C

4.1: methanol; sodium hydroxide; water / 12 h / 22 °C

4.2: 40 °C / 0.75 Torr / pH 5

With hydrogenchloride; methanol; sodium hydroxide; water; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; DMF (N,N-dimethyl-formamide);