[(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate

Base Information

Chemical Name:[(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate
CAS No.:1369768-29-5
Molecular Formula:C₁₃H₁₅FO₃
Molecular Weight:238.259
Hs Code.:

Synonyms:[(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate

Suppliers and Price of [(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 12 raw suppliers

Chemical Property of [(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate

Chemical Property:

Purity/Quality:: 99%HPLC ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate

There total 8 articles about [(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 108-05-4,9003-20-7
vinyl acetate

: 1369767-20-3
((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

: 1369768-29-5
[(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate

Guidance literature:: With lipase acrylic resin from Candida antarctica; In tetrahydrofuran; at 20 ℃; for 17h; Cooling with ice; Enzymatic reaction;
DOI:10.1021/acs.jmedchem.5b00217

Reference yield:

: 108-05-4,9003-20-7
vinyl acetate

: 1369767-20-3
((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

: 1369768-29-5
[(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate

: 1369768-30-8
C₁₅H₁₇FO₄

Guidance literature:: With Candida Antarctica Lipase B; In 2-methyltetrahydrofuran; at 20 - 25 ℃; Inert atmosphere; Enzymatic reaction;

Reference yield:

: 501-00-8
3-fluorophenylacetonitrile

: 1369768-29-5
[(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 °C

1.2: 8 h / Reflux

1.3: 3 h / 0 - 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C

3.1: lipase acrylic resin from Candida antarctica / 17 h / 20 °C / Enzymatic reaction

With sodium tetrahydroborate; lipase acrylic resin from Candida antarctica; sodium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.1021/jm400772t