(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarbaldehyde

Base Information

Chemical Name:(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarbaldehyde
CAS No.:1369767-26-9
Molecular Formula:C₁₇H₁₇FN₂O₂
Molecular Weight:300.333
Hs Code.:

Synonyms:(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarbaldehyde

Suppliers and Price of (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarbaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarbaldehyde

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarbaldehyde

There total 12 articles about (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369767-24-7
((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)methanol

: 1369767-26-9
(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarbaldehyde

Guidance literature:: With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In aq. phosphate buffer; toluene; at 0 - 20 ℃; for 2h; pH=7;

Reference yield:

: 1369768-29-5
[(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate

: 1369767-26-9
(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 2-methyltetrahydrofuran / 1 h / 10 - 15 °C / Inert atmosphere

2: caesium carbonate / acetonitrile / 65 - 70 °C / Inert atmosphere

3: water; sodium hydroxide / acetonitrile / 20 - 25 °C

4: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / toluene; aq. phosphate buffer / 2 h / 0 - 20 °C / pH 7

With pyridine; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; caesium carbonate; sodium hydroxide; In 2-methyltetrahydrofuran; aq. phosphate buffer; toluene; acetonitrile;

Reference yield:

: 1450904-94-5
C₁₉H₂₁FN₂O₃

: 1369767-26-9
(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / acetonitrile / 20 - 25 °C

2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / toluene; aq. phosphate buffer / 2 h / 0 - 20 °C / pH 7

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; sodium hydroxide; In aq. phosphate buffer; toluene; acetonitrile;