methyl 4-((4E/Z)-3-(4-cyanobenzyl)-5-{5-fluoro-2-[2-(4-methoxyphenyl)ethyl]phenyl}pent-4-en-1-yl)benzoate

Base Information

Chemical Name:methyl 4-((4E/Z)-3-(4-cyanobenzyl)-5-{5-fluoro-2-[2-(4-methoxyphenyl)ethyl]phenyl}pent-4-en-1-yl)benzoate
CAS No.:935253-32-0
Molecular Formula:C₃₆H₃₄FNO₃
Molecular Weight:547.669
Hs Code.:

Synonyms:methyl 4-((4E/Z)-3-(4-cyanobenzyl)-5-{5-fluoro-2-[2-(4-methoxyphenyl)ethyl]phenyl}pent-4-en-1-yl)benzoate

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Chemical Property of methyl 4-((4E/Z)-3-(4-cyanobenzyl)-5-{5-fluoro-2-[2-(4-methoxyphenyl)ethyl]phenyl}pent-4-en-1-yl)benzoate

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Technology Process of methyl 4-((4E/Z)-3-(4-cyanobenzyl)-5-{5-fluoro-2-[2-(4-methoxyphenyl)ethyl]phenyl}pent-4-en-1-yl)benzoate

There total 12 articles about methyl 4-((4E/Z)-3-(4-cyanobenzyl)-5-{5-fluoro-2-[2-(4-methoxyphenyl)ethyl]phenyl}pent-4-en-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 934738-17-7
methyl 4-[3-(4-cyanobenzyl)-4-oxobutyl]benzoate

: 934753-12-5
{5-Fluoro-2-[2-(4-methoxyphenyl)ethyl]benzyl}triphenylphosphonium bromide

: 935253-32-0
methyl 4-((4E/Z)-3-(4-cyanobenzyl)-5-{5-fluoro-2-[2-(4-methoxyphenyl)ethyl]phenyl}pent-4-en-1-yl)benzoate

Guidance literature:: With n-butyllithium; In hexane; at 0 - 20 ℃;

Reference yield:

: 637-69-4,24936-44-5
4-Methoxystyrene

: 935253-32-0
methyl 4-((4E/Z)-3-(4-cyanobenzyl)-5-{5-fluoro-2-[2-(4-methoxyphenyl)ethyl]phenyl}pent-4-en-1-yl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0 - 20 °C

3: hydrogen / palladium on activated charcoal / methanol; ethanol / 1 h / 20 °C / 760.05 Torr

4: acetonitrile / Reflux

5: n-butyllithium / hexane / 0 - 20 °C

With sodium tetrahydroborate; n-butyllithium; hydrogen; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; palladium on activated charcoal; In methanol; ethanol; hexane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 934753-09-0
(E)-5-fluoro-2-(4-methoxystyryl)benzaldehyde

: 935253-32-0
methyl 4-((4E/Z)-3-(4-cyanobenzyl)-5-{5-fluoro-2-[2-(4-methoxyphenyl)ethyl]phenyl}pent-4-en-1-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 0 - 20 °C

2: hydrogen / palladium on activated charcoal / methanol; ethanol / 1 h / 20 °C / 760.05 Torr

3: acetonitrile / Reflux

4: n-butyllithium / hexane / 0 - 20 °C

With sodium tetrahydroborate; n-butyllithium; hydrogen; palladium on activated charcoal; In methanol; ethanol; hexane; acetonitrile;