di-tert-butyl N--N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-D-alaninate

Base Information

Chemical Name:di-tert-butyl N--N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-D-alaninate
CAS No.:145788-97-2
Molecular Formula:C₃₆H₄₅N₅O₇
Molecular Weight:659.783
Hs Code.:

di-tert-butyl N-<N-<4-<N-<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>-N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-D-alaninate

Synonyms:di-tert-butyl N--N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-D-alaninate

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Chemical Property of di-tert-butyl N--N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-D-alaninate

Chemical Property:

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Technology Process of di-tert-butyl N--N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-D-alaninate

There total 4 articles about di-tert-butyl N--N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-D-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 138899-84-0
4--N-prop-2-ynylamino>benzoic acid, trifluoroacetate salt

: 145788-96-1
di-tert-butyl L-γ-glutamyl-D-alaninate

: 145788-97-2
di-tert-butyl N--N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-D-alaninate

Guidance literature:: With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.16667h;
DOI:10.1021/jm950471+

Reference yield:

: 5891-45-2
(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

: 145788-97-2
di-tert-butyl N--N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-D-alaninate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -20 deg C, 10 min, 2.) THF, a) -20 deg C, 10 min, b) RT, 1.5 h

2: 97 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / Ambient temperature

3: 44 percent / DEPC, Et₃N / dimethylformamide / 2.17 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogen; triethylamine; diethyl dicarbonate; isobutyl chloroformate; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950471+

Reference yield:

: 13404-22-3,59531-86-1,69320-88-3
tert butyl D-alaninate hydrochloride

: 145788-97-2
di-tert-butyl N--N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-D-alaninate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -20 deg C, 10 min, 2.) THF, a) -20 deg C, 10 min, b) RT, 1.5 h

2: 97 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / Ambient temperature

3: 44 percent / DEPC, Et₃N / dimethylformamide / 2.17 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogen; triethylamine; diethyl dicarbonate; isobutyl chloroformate; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950471+