138899-84-0

Basic information

• Product Name: Benzoic acid, 4-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino] -, mono(trifluoroacetate)
• CAS NO: 138899-84-0
• Molecular Formula: C20H17N3O3.C2HF3O2
• Molecular Weight: 461.397
• Mol File: 138899-84-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino] -, mono(trifluoroacetate)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino] -, mono(trifluoroacetate)(138899-84-0)
• EPA Substance Registry System: Benzoic acid, 4-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino] -, mono(trifluoroacetate)(138899-84-0)

Safety Data

• Hazardous Substances Data: 138899-84-0(Hazardous Substances Data)

Upstream product

• 18144-47-3 tert-butyl 4-aminobenzoate 
• 112888-43-4 4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline 
• 112888-77-4 tert-butyl 4--N-prop-2-ynylamino>benzoate 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 197223-42-0 tert-butyl (2S)-2-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-5-[(1S)-1,3-di(tert-butoxycarbonyl)propylamino]pentanoate 
• 197223-27-1 ethyl (2S)-2-[(4S)-4-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate 
• 158805-19-7 (S)-2-((S)-4-tert-Butoxycarbonyl-2,2-dimethyl-4-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyrylamino)-pentanedioic acid di-tert-butyl ester 

Relevant articles and documents

Quinazoline antifolate thymidylate synthase inhibitors: Replacement of glutamic acid in the C2-methyl series

The synthesis of a series of analogues of the potent thymidylate synthase (TS) inhibitor N-[4[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N- prop-2-ynylamino]benzoyl]-L-glutamic acid (ICI 198583, 1) is described in which the glutamic acid residu

Syntheses and Thymidylate Synthase Inhibitory Activity of the Poly-γ-glutamyl Conjugates of N--2-thenoyl>-L-glutamic Acid (ICI D1694) and Other Quinazoline Antifolates

Thirteen poly-γ-glutamates derived from several novel antifolates have been synthesized by a convergent route.The syntheses of poly-γ-glutamyl conjugates of N--2-thenoyl>-L-glutamic aci