Technology Process of 2-isobutyl-4-oxo-5,5-diphenylpentanoic acid
There total 6 articles about 2-isobutyl-4-oxo-5,5-diphenylpentanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) 1,1'-carbonyldiimidazole / 1.) THF, 0 deg C, 0.5 h; room temperature, overnight, 2.) THF, hexane, -78 deg C, 0.5 h
2: 1.) NaH / 1.) THF, room temperature, overnight, 2.) TFA, room temperature, 3.) benzene, reflux
3: LiOH*H2O / methanol; H2O / 70 - 75 °C
With
lithium hydroxide; sodium hydride; 1,1'-carbonyldiimidazole;
In
methanol; water;
DOI:10.1016/S0968-0896(98)00009-1
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) NaH / 1.) THF, room temperature, overnight, 2.) TFA, room temperature, 3.) benzene, reflux
2: LiOH*H2O / methanol; H2O / 70 - 75 °C
With
lithium hydroxide; sodium hydride;
In
methanol; water;
DOI:10.1016/S0968-0896(98)00009-1
