(R)-2-Isobutyl-4-oxo-5,5-diphenyl-pentanoic acid methyl ester

Base Information

• Chemical Name: (R)-2-Isobutyl-4-oxo-5,5-diphenyl-pentanoic acid methyl ester
• CAS No.: 209664-19-7
• Molecular Formula: C₂₂H₂₆O₃
• Molecular Weight: 338.447
• Mol file: 209664-19-7.mol

Synonyms:(R)-2-Isobutyl-4-oxo-5,5-diphenyl-pentanoic acid methyl ester

Chemical Property of (R)-2-Isobutyl-4-oxo-5,5-diphenyl-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-Isobutyl-4-oxo-5,5-diphenyl-pentanoic acid methyl ester

There total 5 articles about (R)-2-Isobutyl-4-oxo-5,5-diphenyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-4-Methyl-2-trifluoromethanesulfonyloxy-pentanoic acid methyl ester (153396-63-5) → (R)-2-Isobutyl-4-oxo-5,5-diphenyl-pentanoic acid methyl ester (209664-19-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 23 °C

2: TFA / H₂O / 23 °C

3: benzene / Heating

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; water; benzene;

DOI:10.1016/S0960-894X(96)00286-7

Reference yield:

(R)-2-Diphenylacetyl-3-isobutyl-succinic acid 1-tert-butyl ester 4-methyl ester → (R)-2-Isobutyl-4-oxo-5,5-diphenyl-pentanoic acid methyl ester (209664-19-7)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA / H₂O / 23 °C

2: benzene / Heating

With trifluoroacetic acid; In water; benzene;

DOI:10.1016/S0960-894X(96)00286-7

Reference yield:

(R)-2-Diphenylacetyl-3-isobutyl-succinic acid 4-methyl ester → (R)-2-Isobutyl-4-oxo-5,5-diphenyl-pentanoic acid methyl ester (209664-19-7)

Guidance literature:

In benzene; Heating;

DOI:10.1016/S0960-894X(96)00286-7

upstream raw materials:

(R)-4-Methyl-2-trifluoromethanesulfonyloxy-pentanoic acid methyl ester

3-Oxo-4,4-diphenyl-butyric acid tert-butyl ester

2,2-diphenylacetic acid

Downstream raw materials:

(R)-2-isobutyl-4-oxo-5,5-diphenylpentanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

2-isobutyl-4-oxo-5,5-diphenylpentanoic acid