Technology Process of (8S,9S,E)-9-(3,5-bis((triisopropylsilyl)oxy)phenyl)-3,3,11,11-tetraethyl-5-((2S,4S)-5-((4-methoxybenzyl)oxy)-4-methylpentan-2-yl)-8-methyl-4,10-dioxa-3,11-disilatridec-6-ene
There total 12 articles about (8S,9S,E)-9-(3,5-bis((triisopropylsilyl)oxy)phenyl)-3,3,11,11-tetraethyl-5-((2S,4S)-5-((4-methoxybenzyl)oxy)-4-methylpentan-2-yl)-8-methyl-4,10-dioxa-3,11-disilatridec-6-ene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine;
In
dichloromethane;
at 0 - 20 ℃;
for 1.5h;
Inert atmosphere;
DOI:10.1021/ol200834p
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
2: C5H5N*HO3S; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C
3: chromium dichloride; nickel dichloride / tetrahydrofuran; dimethyl sulfoxide / 17 h / 20 °C / Inert atmosphere; Large scale reaction
4: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere
With
2,6-dimethylpyridine; chromium dichloride; C5H5N*HO3S; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; nickel dichloride;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
3: Nozaki-Hiyama-Kishi reaction;
DOI:10.1021/ol200834p
- Guidance literature:
-
Multi-step reaction with 3 steps
1: C5H5N*HO3S; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C
2: chromium dichloride; nickel dichloride / tetrahydrofuran; dimethyl sulfoxide / 17 h / 20 °C / Inert atmosphere; Large scale reaction
3: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere
With
2,6-dimethylpyridine; chromium dichloride; C5H5N*HO3S; N-ethyl-N,N-diisopropylamine; nickel dichloride;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
2: Nozaki-Hiyama-Kishi reaction;
DOI:10.1021/ol200834p
