N-[(1Z)-4,4-difluoro-2,2-dimethyl-1-(2-phenylethylidene)but-3-en-1-yl]-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-[(1Z)-4,4-difluoro-2,2-dimethyl-1-(2-phenylethylidene)but-3-en-1-yl]-4-methylbenzenesulfonamide
CAS No.:1629871-01-7
Molecular Formula:C₂₁H₂₃F₂NO₂S
Molecular Weight:391.482
Hs Code.:

Synonyms:N-[(1Z)-4,4-difluoro-2,2-dimethyl-1-(2-phenylethylidene)but-3-en-1-yl]-4-methylbenzenesulfonamide

Suppliers and Price of N-[(1Z)-4,4-difluoro-2,2-dimethyl-1-(2-phenylethylidene)but-3-en-1-yl]-4-methylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(1Z)-4,4-difluoro-2,2-dimethyl-1-(2-phenylethylidene)but-3-en-1-yl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(1Z)-4,4-difluoro-2,2-dimethyl-1-(2-phenylethylidene)but-3-en-1-yl]-4-methylbenzenesulfonamide

There total 5 articles about N-[(1Z)-4,4-difluoro-2,2-dimethyl-1-(2-phenylethylidene)but-3-en-1-yl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1629870-87-6
N-[4,4-difluoro-2,2-dimethyl-1-(2-phenylethyl)but-3-en-1-ylidene]-4-methylbenzenesulfonamide

: 1629871-01-7
N-[(1Z)-4,4-difluoro-2,2-dimethyl-1-(2-phenylethylidene)but-3-en-1-yl]-4-methylbenzenesulfonamide

Guidance literature:: With potassium hydride; In tetrahydrofuran; mineral oil; for 2h; stereoselective reaction; Reflux; Inert atmosphere;
DOI:10.1055/s-0033-1340857

Reference yield:

: 1426575-59-8
2,2-dimethyl-3-oxo-5-phenylpentanal

: 1629871-01-7
N-[(1Z)-4,4-difluoro-2,2-dimethyl-1-(2-phenylethylidene)but-3-en-1-yl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.25 h / -78 - 20 °C / Molecular sieve; Inert atmosphere

1.2: 16 h / Inert atmosphere

2.1: triethylamine / 0.08 h / 0 °C / Inert atmosphere

2.2: 24 h / 0 °C / Reflux; Inert atmosphere

3.1: potassium hydride / tetrahydrofuran; mineral oil / 2 h / Reflux; Inert atmosphere

With potassium hydride; triethylamine; Hexamethylphosphorous triamide; In tetrahydrofuran; mineral oil;
DOI:10.1055/s-0033-1340857

Reference yield:

: 645-45-4
hydrocinnamic acid chloride

: 1629871-01-7
N-[(1Z)-4,4-difluoro-2,2-dimethyl-1-(2-phenylethylidene)but-3-en-1-yl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether / 12 h / 0 °C / Reflux; Inert atmosphere

2.1: sodium hydrogencarbonate / water / 1 h / 0 °C / Inert atmosphere

3.1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.25 h / -78 - 20 °C / Molecular sieve; Inert atmosphere

3.2: 16 h / Inert atmosphere

4.1: triethylamine / 0.08 h / 0 °C / Inert atmosphere

4.2: 24 h / 0 °C / Reflux; Inert atmosphere

5.1: potassium hydride / tetrahydrofuran; mineral oil / 2 h / Reflux; Inert atmosphere

With potassium hydride; sodium hydrogencarbonate; triethylamine; Hexamethylphosphorous triamide; In tetrahydrofuran; diethyl ether; water; mineral oil;
DOI:10.1055/s-0033-1340857