N-[4,4-difluoro-2,2-dimethyl-1-(2-phenylethyl)but-3-en-1-ylidene]-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-[4,4-difluoro-2,2-dimethyl-1-(2-phenylethyl)but-3-en-1-ylidene]-4-methylbenzenesulfonamide
CAS No.:1629870-87-6
Molecular Formula:C₂₁H₂₃F₂NO₂S
Molecular Weight:391.482
Hs Code.:

Synonyms:N-[4,4-difluoro-2,2-dimethyl-1-(2-phenylethyl)but-3-en-1-ylidene]-4-methylbenzenesulfonamide

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Chemical Property of N-[4,4-difluoro-2,2-dimethyl-1-(2-phenylethyl)but-3-en-1-ylidene]-4-methylbenzenesulfonamide

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Technology Process of N-[4,4-difluoro-2,2-dimethyl-1-(2-phenylethyl)but-3-en-1-ylidene]-4-methylbenzenesulfonamide

There total 4 articles about N-[4,4-difluoro-2,2-dimethyl-1-(2-phenylethyl)but-3-en-1-ylidene]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1426575-50-9
6,6-difluoro-4,4-dimethyl-1-phenylhex-5-en-3-one

: 70-55-3
toluene-4-sulfonamide

: 1629870-87-6
N-[4,4-difluoro-2,2-dimethyl-1-(2-phenylethyl)but-3-en-1-ylidene]-4-methylbenzenesulfonamide

Guidance literature:: 6,6-difluoro-4,4-dimethyl-1-phenylhex-5-en-3-one; toluene-4-sulfonamide; With triethylamine; at 0 ℃; for 0.0833333h; Inert atmosphere;

With titanium tetrachloride; at 0 ℃; for 24h; Reflux; Inert atmosphere;
DOI:10.1055/s-0033-1340857

Reference yield:

: 1426575-59-8
2,2-dimethyl-3-oxo-5-phenylpentanal

: 1629870-87-6
N-[4,4-difluoro-2,2-dimethyl-1-(2-phenylethyl)but-3-en-1-ylidene]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.25 h / -78 - 20 °C / Molecular sieve; Inert atmosphere

1.2: 16 h / Inert atmosphere

2.1: triethylamine / 0.08 h / 0 °C / Inert atmosphere

2.2: 24 h / 0 °C / Reflux; Inert atmosphere

With triethylamine; Hexamethylphosphorous triamide; In tetrahydrofuran;
DOI:10.1055/s-0033-1340857

Reference yield:

: 645-45-4
hydrocinnamic acid chloride

: 1629870-87-6
N-[4,4-difluoro-2,2-dimethyl-1-(2-phenylethyl)but-3-en-1-ylidene]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether / 12 h / 0 °C / Reflux; Inert atmosphere

2.1: sodium hydrogencarbonate / water / 1 h / 0 °C / Inert atmosphere

3.1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.25 h / -78 - 20 °C / Molecular sieve; Inert atmosphere

3.2: 16 h / Inert atmosphere

4.1: triethylamine / 0.08 h / 0 °C / Inert atmosphere

4.2: 24 h / 0 °C / Reflux; Inert atmosphere

With sodium hydrogencarbonate; triethylamine; Hexamethylphosphorous triamide; In tetrahydrofuran; diethyl ether; water;
DOI:10.1055/s-0033-1340857