(S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid benzyl ester

Base Information

Chemical Name:(S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid benzyl ester
CAS No.:127462-49-1
Molecular Formula:C₃₁H₄₆N₂O₆Si
Molecular Weight:570.802
Hs Code.:

Synonyms:(S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid benzyl ester

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Chemical Property of (S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid benzyl ester

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Technology Process of (S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid benzyl ester

There total 5 articles about (S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 129453-35-6
O-tert-butyldimethylsilyl-N-methyl-D-tyrosine benzyl ester

: 33294-53-0,89028-47-7
N-Boc-L-alanine anhydride

: 127462-49-1
(S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 10h; Ambient temperature;

Reference yield:

: 42406-77-9
L-tyrosine benzyl ester

: 127462-49-1
(S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 91.2 percent / Et₃N / dioxane; H₂O / 24 h / Ambient temperature

2: 93.3 percent / imidazole / dimethylformamide / 7 h / Ambient temperature

3: 82 percent / NaH / dimethylformamide / 3 h

4: 84.9 percent / TFA / CH₂Cl₂ / 4 h / 0 °C

5: 91 percent / Et₃N / CH₂Cl₂ / 10 h / Ambient temperature

With 1H-imidazole; sodium hydride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 19391-35-6
N-tert-butoxycarbonyl-L-tyrosine benzyl ester

: 127462-49-1
(S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 93.3 percent / imidazole / dimethylformamide / 7 h / Ambient temperature

2: 82 percent / NaH / dimethylformamide / 3 h

3: 84.9 percent / TFA / CH₂Cl₂ / 4 h / 0 °C

4: 91 percent / Et₃N / CH₂Cl₂ / 10 h / Ambient temperature

With 1H-imidazole; sodium hydride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;