Antibiotic K 252a

Base Information

Chemical Name:Antibiotic K 252a
CAS No.:99533-80-9
Deprecated CAS:105450-17-7,108645-76-7,151004-74-9
Molecular Formula:C₂₇H₂₁N₃O₅
Molecular Weight:467.481
Hs Code.:29349990
European Community (EC) Number:640-127-4
UNII:IV7H45AM5B
DSSTox Substance ID:DTXSID40880065
Wikipedia:K252a
Wikidata:Q5931064
NCI Thesaurus Code:C1382
Pharos Ligand ID:KBZD8QKCM3MX
Metabolomics Workbench ID:98407
ChEMBL ID:CHEMBL281948

Synonyms:3'-(S)-epi-K-252a;K 252;K 252a;K 252b;K 252c;K 252d;K-252;K-252a;K-252b;K-252d;K252a;staurosporine aglycone;staurosporinone

Suppliers and Price of Antibiotic K 252a

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
K252a
50mg
$ 1390.00

TRC
K252a
0.5mg
$ 95.00

Sigma-Aldrich
K-252a fromNocardiopsissp.
100 μg
$ 134.00

Sigma-Aldrich
K-252a from Nocardiopsis sp.
100ug-f
$ 129.00

Sigma-Aldrich
K-252a fromNonomuraealongicatena,≥98%(HPLC)
100 μg
$ 188.00

Sigma-Aldrich
K-252a ReadyMadeSolution,fromNonomuraealongicatena,>98%
200 μL
$ 186.00

Sigma-Aldrich
K-252a from Nonomuraea longicatena, ≥98% (HPLC)
100ug
$ 181.00

Sigma-Aldrich
K-252a Ready Made Solution, from Nonomuraea longicatena, >98%
200ul
$ 179.00

Sigma-Aldrich
K-252a from Nocardiopsis sp., ≥96.0% (HPLC)
1mg
$ 3080.00

ChemScene
K-252a 99.45%
1mg
$ 330.00

Total 21 raw suppliers

Chemical Property of Antibiotic K 252a

Chemical Property:

Vapor Pressure:1.02E-19mmHg at 25°C
Melting Point:262-273℃ (decomposition) (methanol )
Boiling Point:685.3°Cat760mmHg
PKA:11.95±0.40(Predicted)
Flash Point:368.2°C
PSA：94.72000
Density:1.67g/cm³
LogP:3.98390
Storage Temp.:−20°C
Solubility.:DMF: 1 mg/mL
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:467.14812078
Heavy Atom Count:35
Complexity:977

Purity/Quality:

99%, ^*data from raw suppliers

K252a ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi,T
Statements: 61-20/21/22-68/20/21/22
Safety Statements: 22-24/25-45-36/37-53

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Isomeric SMILES:C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Recent ClinicalTrials:Hepatotoxicity Related to Protein Kinase Inhibitors
Description K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein kinase (PK) C, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase with IC50 values of 470, 140, 270, and 1.7 nM, respectively. Because it inhibits neurotrophin receptor tyrosine kinases, K252a at 100-500 nM has been used to suppress trophoblast proliferation and increase apoptosis associated with the disruption of mitochondrial functions in cultured choriocarcinoma cells. Recently, K252a has been shown to inhibit PRK1 (IC50 = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11 and is involved in androgen-dependent gene expression.
Uses K-252a is used to inhibit protein kinases involved in cell signaling processes, including CaM kinase; phosphorylase kinase, serine/threonine kinases, Trk. It is used to inhibit the actions of nerve growth factor (NGF) on PC1 2 cells and to inhibit smooth muscle myosin light chain kinase .

Technology Process of Antibiotic K 252a

There total 22 articles about Antibiotic K 252a which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 188028-91-3
C₃₆H₃₁N₃O₇

: 99533-80-9,97161-97-2
K-252a

Guidance literature:: With methyl-phenyl-thioether; trifluoroacetic acid; In dichloromethane; at 25 ℃; for 6h;
DOI:10.1021/ja9713035

Reference yield: 75.0%

: 77-78-1
dimethyl sulfate

: 99570-78-2
K-252b

: 99533-80-9,97161-97-2
K-252a

Guidance literature:: With potassium carbonate; In N,N-dimethyl acetamide; at 30 ℃; for 6h;
DOI:10.1271/bbb.62.1627

Reference yield:

: (9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(carboxylate)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one sodium salt

: 80-48-8
methyl p-toluene sulfonate

: 99533-80-9,97161-97-2
K-252a

Guidance literature:: (9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(carboxylate)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one sodium salt; methyl p-toluene sulfonate; With sodium hydrogencarbonate; In N,N-dimethyl acetamide; at 40 ℃; for 3 - 4h;

With sodium acetate; In water; at 20 ℃; for 4h;