2-({1-[2-(3-benzyloxyphenyl)ethyl]piperidin-4-yl}carbonyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:2-({1-[2-(3-benzyloxyphenyl)ethyl]piperidin-4-yl}carbonyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1344029-81-7
Molecular Formula:C₃₃H₃₉FN₂O₂
Molecular Weight:514.683
Hs Code.:

Synonyms:2-({1-[2-(3-benzyloxyphenyl)ethyl]piperidin-4-yl}carbonyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 2-({1-[2-(3-benzyloxyphenyl)ethyl]piperidin-4-yl}carbonyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 2-({1-[2-(3-benzyloxyphenyl)ethyl]piperidin-4-yl}carbonyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinoline

There total 6 articles about 2-({1-[2-(3-benzyloxyphenyl)ethyl]piperidin-4-yl}carbonyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1344029-26-0
2-(3-benzyloxyphenyl)ethyl p-toluenesulfonate

: 1344029-15-7
4-[(6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl]piperidine

: 1344029-81-7
2-({1-[2-(3-benzyloxyphenyl)ethyl]piperidin-4-yl}carbonyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With potassium carbonate; In acetonitrile; at 70 ℃; for 15h;
DOI:10.1248/cpb.59.1029

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1344029-81-7
2-({1-[2-(3-benzyloxyphenyl)ethyl]piperidin-4-yl}carbonyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: lithium aluminium tetrahydride / tetrahydrofuran

3: pyridine / 1,2-dichloro-ethane

4: potassium carbonate / acetonitrile / 15 h / 70 °C

With pyridine; lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.59.1029

Reference yield:

: 177259-98-2
2-[(3-(benzyloxy)phenyl)]ethan-1-ol

: 1344029-81-7
2-({1-[2-(3-benzyloxyphenyl)ethyl]piperidin-4-yl}carbonyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1,2-dichloro-ethane

2: potassium carbonate / acetonitrile / 15 h / 70 °C

With pyridine; potassium carbonate; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1248/cpb.59.1029