2-(3-(Benzyloxy)phenyl)ethanol

Base Information

• Chemical Name: 2-(3-(Benzyloxy)phenyl)ethanol
• CAS No.: 177259-98-2
• Molecular Formula: C15H16O2
• Molecular Weight: 228.28600
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID30606812
• Wikidata: Q82505668
• Mol file: 177259-98-2.mol

Synonyms:2-(3-(BENZYLOXY)PHENYL)ETHANOL;177259-98-2;2-(3-phenylmethoxyphenyl)ethanol;Benzeneethanol, 3-(phenylmethoxy)-;2-(3-(Benzyloxy)phenyl)ethan-1-ol;2-[3-(benzyloxy)phenyl]ethanol;MFCD09926272;2-[3-(Benzyloxy)phenyl]ethan-1-ol;SCHEMBL3179250;DTXSID30606812;RHHVCIKVRLMNFC-UHFFFAOYSA-N;BDBM558271;CHA25998;AKOS027252458;US11365192, Example 24-2;AM803363;AS-30046;SY124538;DB-337550;CS-0037779;Sodium 2-methyl-2-[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl] oxymethyl]phenyl]propanoate

Chemical Property of 2-(3-(Benzyloxy)phenyl)ethanol

Chemical Property:

• PSA: 29.46000
• LogP: 2.80040
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 228.115029749
• Heavy Atom Count: 17
• Complexity: 199

Purity/Quality:

99% ^*data from raw suppliers

2-(3-Phenylmethoxyphenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=CC(=C2)CCO

Technology Process of 2-(3-(Benzyloxy)phenyl)ethanol

There total 7 articles about 2-(3-(Benzyloxy)phenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(3-hydroxyphenyl)ethanol (13398-94-2) + benzyl bromide (100-39-0) → 2-[(3-(benzyloxy)phenyl)]ethan-1-ol (177259-98-2)

Guidance literature:

2-(3-hydroxyphenyl)ethanol; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1021/acs.jmedchem.8b01466

Reference yield: 62.0%

3-benzyloxy-phenylacetic acid methyl ester (62969-42-0) → 2-[(3-(benzyloxy)phenyl)]ethan-1-ol (177259-98-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1248/cpb.59.1029

Reference yield: 46.0%

oxirane (75-21-8,99932-75-9) + 3-(benzyloxy)phenyl bromide (53087-13-1) → 2-[(3-(benzyloxy)phenyl)]ethan-1-ol (177259-98-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 25 ℃; for 2h; Inert atmosphere;

upstream raw materials:

2-(3-hydroxyphenyl)ethanol

benzyl bromide

3-benzyloxy-phenylacetic acid methyl ester

m-hydroxyphenylacetic acid

Downstream raw materials:

1-ethynyl-3-(phenylmethoxy)benzene

(+/-)-WMS-1418

(+/-)-7-benzyloxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol