trans-11,12-dideuteroretinol

Base Information

Chemical Name:trans-11,12-dideuteroretinol
CAS No.:58508-29-5
Molecular Formula:C₂₀H₃₀O
Molecular Weight:288.442
Hs Code.:

Synonyms:trans-11,12-dideuteroretinol

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Chemical Property of trans-11,12-dideuteroretinol

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Technology Process of trans-11,12-dideuteroretinol

There total 3 articles about trans-11,12-dideuteroretinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1430344-90-3
(2E,4E)-5-(benzyldimethylsilyl)-4,5-dideutero-3-methylpenta-2,4-dien-1-ol

: 138846-06-7
2-[(1’E,3’E)-3’-methyl-4’-iodobuta-1’,3’-dien-1’yl]-1,3,3-trimethylcyclohex-1-ene

: 58508-29-5
trans-11,12-dideuteroretinol

Guidance literature:: (2E,4E)-5-(benzyldimethylsilyl)-4,5-dideutero-3-methylpenta-2,4-dien-1-ol; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere; Darkness;

2-[(1’E,3’E)-3’-methyl-4’-iodobuta-1’,3’-dien-1’yl]-1,3,3-trimethylcyclohex-1-ene; With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; for 1h; Inert atmosphere; Darkness;
DOI:10.1002/chem.201202260

Reference yield:

: 1430344-94-7
(E)-2-[(5-deutero-3-methylpent-2-en-4-yn-1-yl)oxy]tetrahydro-2H-pyran

: 58508-29-5
trans-11,12-dideuteroretinol

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / methanol / 0.25 h / Inert atmosphere

2.1: platinum⁽⁰⁾-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex; tri-tert-butyl phosphine / tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene / 0.5 h / Inert atmosphere

2.2: Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere; Darkness

3.2: 1 h / Inert atmosphere; Darkness

With platinum⁽⁰⁾-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; 3.1: |Hiyama Coupling / 3.2: |Hiyama Coupling;
DOI:10.1002/chem.201202260

Reference yield:

: 1430344-93-6
(E)-3-methylpent-2-en-4-yn-1-ol

: 58508-29-5
trans-11,12-dideuteroretinol

Guidance literature:: Multi-step reaction with 2 steps

1.1: platinum⁽⁰⁾-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex; tri-tert-butyl phosphine / tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene / 0.5 h / Inert atmosphere

1.2: Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere; Darkness

2.2: 1 h / Inert atmosphere; Darkness

With platinum⁽⁰⁾-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; 2.1: |Hiyama Coupling / 2.2: |Hiyama Coupling;
DOI:10.1002/chem.201202260