methyl (2S,3aR,7aR)-1-benzyl-6-oxooctahydroindole-2-carboxylate ethylene acetal

Base Information

Chemical Name:methyl (2S,3aR,7aR)-1-benzyl-6-oxooctahydroindole-2-carboxylate ethylene acetal
CAS No.:908290-16-4
Molecular Formula:C₁₉H₂₅NO₄
Molecular Weight:331.412
Hs Code.:

Synonyms:methyl (2S,3aR,7aR)-1-benzyl-6-oxooctahydroindole-2-carboxylate ethylene acetal

Suppliers and Price of methyl (2S,3aR,7aR)-1-benzyl-6-oxooctahydroindole-2-carboxylate ethylene acetal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2S,3aR,7aR)-1-benzyl-6-oxooctahydroindole-2-carboxylate ethylene acetal

Chemical Property:

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Technology Process of methyl (2S,3aR,7aR)-1-benzyl-6-oxooctahydroindole-2-carboxylate ethylene acetal

There total 1 articles about methyl (2S,3aR,7aR)-1-benzyl-6-oxooctahydroindole-2-carboxylate ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-21-1
ethylene glycol

: 181649-56-9
methyl (2S,3aR,7aR)-1-benzyl-6-oxo-octahydroindole-2-carboxylate

: 908290-16-4
methyl (2S,3aR,7aR)-1-benzyl-6-oxooctahydroindole-2-carboxylate ethylene acetal

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 4h; Heating;
DOI:10.1021/jo060592p

Reference yield:

: 908290-16-4
methyl (2S,3aR,7aR)-1-benzyl-6-oxooctahydroindole-2-carboxylate ethylene acetal

: 908290-18-6
(2S,3aR,7aR)-1-benzyl-2-hydroxymethyl-6-oxooctahydroindole ethylene acetal

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/jo060592p

Reference yield:

: 908290-16-4
methyl (2S,3aR,7aR)-1-benzyl-6-oxooctahydroindole-2-carboxylate ethylene acetal

: (2S,3aR,7aR)-1-benzyl-2-[(1'S)-1-acetoxyethyl]octahydroindol-6-one ethylene acetal

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0.5 h

1.2: i-PrMgCl / tetrahydrofuran / 0.67 h / cooling

2.1: tetrahydrofuran; diethyl ether / 1 h / 0 °C

3.1: 622 mg / NaBH₄ / methanol / 6 h / -20 °C

4.1: CH₃SO₂Cl; triethylamine / tetrahydrofuran / 4 h / Heating

5.1: 68 percent / tetrahydrofuran / 4 h / Heating

With sodium tetrahydroborate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jo060592p