Technology Process of 4-(3,4-dimethoxyphenyl)pyrimidine-2,5-diamine
There total 3 articles about 4-(3,4-dimethoxyphenyl)pyrimidine-2,5-diamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium methylate / methanol / Reflux
2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 3000.3 Torr
With
palladium 10% on activated carbon; hydrogen; sodium methylate;
In
methanol;
DOI:10.3762/bjoc.8.220
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: thionyl chloride / dichloromethane / 0.5 h / 25 °C
1.2: 2 h / 25 °C
2.1: potassium tert-butylate / dimethyl sulfoxide / 0.17 h / 10 °C
2.2: 8 h / 10 - 20 °C
3.1: dichloromethane / 6 h / 20 °C
4.1: sodium methylate / methanol / Reflux
5.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 3000.3 Torr
With
thionyl chloride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium methylate;
In
methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.3762/bjoc.8.220
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / dimethyl sulfoxide / 0.17 h / 10 °C
1.2: 8 h / 10 - 20 °C
2.1: dichloromethane / 6 h / 20 °C
3.1: sodium methylate / methanol / Reflux
4.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 3000.3 Torr
With
palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium methylate;
In
methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.3762/bjoc.8.220
