333347-81-2

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 93-07-2 Veratric acid 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 

Downstream Products

• 478-01-3 nobiletin 
• 2174-59-6 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone 
• 654083-34-8 1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1,3-propanedione 
• 46729-91-3 1-(3,4-dimethoxyphenyl)-2-nitroethan-1-one 
• 1421635-76-8 4-(3,4-dimethoxyphenyl)pyrimidine-2,5-diamine 
• 1421635-75-7 N,N-dimethyl-5-nitro-4-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine 
• 1421635-73-5 4-(3,4-dimethoxyphenyl)-5-nitropyrimidin-2-amine 
• 1421635-71-3 (E)-1-(3,4-dimethoxyphenyl)-3-(dimethylamino)-2-nitroprop-2-en-1-one 
• 67357-63-5 1-(3,4-dimethoxybenzoyl)imidazolidin-2-one 

Relevant academic research and scientific papers

preparing methods of nobiletin

The present invention provides a process for preparing nobiletin. The present invention relates to a method for preparing nobiletin by using a specific reagent.

Practical Synthesis of Polymethylated Flavones: Nobiletin and Its Desmethyl Derivatives

We present a practical synthesis of the polymethoxylated citrus flavone nobiletin that is suitable for use on a hundred gram scale. Ready availability of this compound and its derivatives will aid detailed chemical-biological investigations of their biological activities, including activation of signaling via the cAMP-dependent protein kinase A/extracellular signal-related protein kinase/cAMP response element-binding protein pathway.

Facile synthesis of N-acylbenzotriazoles from carboxylic acids mediated by 2,4,6-trichloro-1,3,5-triazine and triethylamine

Abstract A facile, efficient, and economic method toward N-acylbenzotriazoles was reported using 2,4,6-trichloro-1,3,5-triazine in combination with triethylamine as a carboxylic acid activator. Through reacting 1H-benzotriazole with the generated triacylated triazine intermediate, a series of N-acylbenzotriazoles could be rapidly prepared in high yields without column chromatography.

Acyloxyphosphonium versus aminophosphonium intermediates: Application to the synthesis of N-acylbenzotriazoles

In attempts to convert carboxylic acids directly into N-acylbenzotriazoles by using Ph3P/I2 as an acid-activating system, the outcome of the reaction is reversed from no reaction to almost quantitative yield of the expected product simply by switching the order of the addition of the reagents to the presumed acyloxyphosphonium intermediate. If triethylamine was present before treatment with 1H-benzotriazole, anhydride was always exclusively generated without a detectable amount of the expected product. However, if the base was applied after the addition of 1H-benzotriazole, the reaction proceeded smoothly to afford N-acylbenzotriazoles in good to excellent yields within short reaction times. 31P NMR spectroscopy revealed the presence of a benzotriazophosphonium species in preventing the formation of the anhydride by attack of the carboxylate anion at the acyl function of the acyloxyphosphonium salt.

Engineering of indole-based tethered biheterocyclic alkaloid meridianin into β-carboline-derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization

A mild, efficient and versatile method has been developed for the construction of a functionalized natural product, meridianin, and its post conversion to pyrimido-β-carboline by cationic π-cyclization. The strategy involves the introduction of an amino g

PET imaging of nobiletin based on a practical total synthesis

A practical synthesis of nobiletin, a polymethoxylated citrus flavone, was accomplished by utilizing our novel flavone synthesis. Synthetic nobiletin was labelled by selective demethylation and rapid incorporation of 11C atom. Positron emission tomography images successfully visualized the brain distribution, which may provide therapeutic benefits in the treatment of Alzheimer's disease. The Royal Society of Chemistry.