tert-butoxycarbonylaminoacetic acid 3,5-bis-(pyridin-3-ylethynyl)benzyl ester

Base Information

Chemical Name:tert-butoxycarbonylaminoacetic acid 3,5-bis-(pyridin-3-ylethynyl)benzyl ester
CAS No.:752224-61-6
Molecular Formula:C₂₈H₂₅N₃O₄
Molecular Weight:467.524
Hs Code.:

Synonyms:tert-butoxycarbonylaminoacetic acid 3,5-bis-(pyridin-3-ylethynyl)benzyl ester

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Chemical Property of tert-butoxycarbonylaminoacetic acid 3,5-bis-(pyridin-3-ylethynyl)benzyl ester

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Technology Process of tert-butoxycarbonylaminoacetic acid 3,5-bis-(pyridin-3-ylethynyl)benzyl ester

There total 3 articles about tert-butoxycarbonylaminoacetic acid 3,5-bis-(pyridin-3-ylethynyl)benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 4530-20-5
BOC-glycine

: 752224-60-5
[3,5-bis-(pyridin-3-ylethynyl)phenyl]methanol

: 752224-61-6
tert-butoxycarbonylaminoacetic acid 3,5-bis-(pyridin-3-ylethynyl)benzyl ester

Guidance literature:: BOC-glycine; With dmap; dicyclohexyl-carbodiimide; In chloroform; at 20 ℃; for 1h;

[3,5-bis-(pyridin-3-ylethynyl)phenyl]methanol; With octadecafluorodecahydronaphthalene (cis+trans); 8;
DOI:10.1021/ol048994b

Reference yield:

: 56990-02-4
3,5-dibromobenzaldehyde

: 752224-61-6
tert-butoxycarbonylaminoacetic acid 3,5-bis-(pyridin-3-ylethynyl)benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 93 percent / NaBH₄ / ethanol; CH₂Cl₂ / 3 h / 20 °C

2.1: 81 percent / Et₃N; CuI; [PdCl₂(PPh₃)2] / 35 h / 90 °C

3.1: DCC; DMAP / CHCl₃ / 1 h / 20 °C

3.2: 98 percent / perfluorodecalin / 8

With dmap; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; triethylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; chloroform;
DOI:10.1021/ol048994b

Reference yield:

: 145691-59-4
(3,5-dibromophenyl)methanol

: 752224-61-6
tert-butoxycarbonylaminoacetic acid 3,5-bis-(pyridin-3-ylethynyl)benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / Et₃N; CuI; [PdCl₂(PPh₃)2] / 35 h / 90 °C

2.1: DCC; DMAP / CHCl₃ / 1 h / 20 °C

2.2: 98 percent / perfluorodecalin / 8

With dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; dicyclohexyl-carbodiimide; In chloroform;
DOI:10.1021/ol048994b