2-((S)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid 2,5-dioxo-pyrrolidin-1-yl ester methyl ester

Base Information

• Chemical Name: 2-((S)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid 2,5-dioxo-pyrrolidin-1-yl ester methyl ester
• CAS No.: 135941-66-1
• Molecular Formula: C₂₆H₂₆N₂O₉
• Molecular Weight: 510.5

Synonyms:2-((S)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid 2,5-dioxo-pyrrolidin-1-yl ester methyl ester

Chemical Property of 2-((S)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid 2,5-dioxo-pyrrolidin-1-yl ester methyl ester

Chemical Property:

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Technology Process of 2-((S)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid 2,5-dioxo-pyrrolidin-1-yl ester methyl ester

There total 4 articles about 2-((S)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid 2,5-dioxo-pyrrolidin-1-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-((S)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid dimethyl ester (116835-54-2) → 2-((S)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid 2,5-dioxo-pyrrolidin-1-yl ester methyl ester (135941-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH

2: DCC

With sodium hydroxide; dicyclohexyl-carbodiimide;

DOI:10.1016/0040-4039(91)80834-S

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 2-((R)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid monomethyl ester → 2-((R)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid 2,5-dioxo-pyrrolidin-1-yl ester methyl ester (135941-66-1)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1016/0040-4039(91)80834-S

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 2-((S)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid monomethyl ester → 2-((S)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid 2,5-dioxo-pyrrolidin-1-yl ester methyl ester (135941-66-1)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1016/0040-4039(91)80834-S

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

2-((R)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid dimethyl ester

2-((S)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid dimethyl ester

Downstream raw materials:

(3S,6R)-6-Benzyl-2,5-dioxo-piperidine-3-carboxylic acid methyl ester

(3R,6R)-6-Benzyl-2,5-dioxo-piperidine-3-carboxylic acid methyl ester

(3S,6S)-6-Benzyl-2,5-dioxo-piperidine-3-carboxylic acid methyl ester

(3R,6S)-6-Benzyl-2,5-dioxo-piperidine-3-carboxylic acid methyl ester

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