2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester

Base Information

Chemical Name:2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester
CAS No.:862080-78-2
Molecular Formula:C₁₇H₂₂O₆S
Molecular Weight:354.424
Hs Code.:

Synonyms:2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester

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Chemical Property of 2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester

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Technology Process of 2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester

There total 2 articles about 2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 862080-75-9
(3R,4S,5R,6S)-1-thia-spiro[4,4]nonane-3,4,6-triol

: 39828-35-8
2,4-dimethoxybenzoyl chloride

: 862080-78-2
2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester

: 2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-3,6-dihydroxy-1-thia-spiro[4.4]non-4-yl ester

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; dmap; In dichloromethane; at 20 ℃; for 9h;
DOI:10.1021/jo0506985

Reference yield:

: 849112-79-4
C₁₁H₁₈O₃S

: 862080-78-2
2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / aq. HCl / tetrahydrofuran / 8 h / 20 °C

2: DABCO; DMAP / CH₂Cl₂ / 9 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; dmap; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0506985

Reference yield: 97.0%

: 862080-78-2
2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 862080-81-7
2,4-Dimethoxy-benzoic acid (1R,4R,5S,11S)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

Guidance literature:: 2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester; With pyridine; silver nitrate; In tetrahydrofuran; at 20 ℃; for 1h;

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1021/jo0506985