diethyl ((5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-yl)methyl)phosphonate

Base Information

• Chemical Name: diethyl ((5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-yl)methyl)phosphonate
• CAS No.: 1381864-98-7
• Molecular Formula: C₁₈H₂₃O₇P
• Molecular Weight: 382.35
• Mol file: 1381864-98-7.mol

Synonyms:diethyl ((5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-yl)methyl)phosphonate

Chemical Property of diethyl ((5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-yl)methyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl ((5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-yl)methyl)phosphonate

There total 5 articles about diethyl ((5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-yl)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(bromomethyl)-5-((4-methoxybenzyl)oxy)-4H-pyran-4-one (898045-01-7) + triethyl phosphite (122-52-1) → diethyl ((5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-yl)methyl)phosphonate (1381864-98-7)

Guidance literature:

In toluene; for 24h; Reflux;

DOI:10.1007/s00044-012-0094-y

Reference yield:

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7) → diethyl ((5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-yl)methyl)phosphonate (1381864-98-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C

2: triethylamine / dichloromethane / 0.17 h / 0 °C

3: sodium bromide / N,N-dimethyl-formamide / 0.33 h / 20 °C

4: toluene / 24 h / Reflux

With potassium carbonate; triethylamine; sodium bromide; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1007/s00044-012-0094-y

Reference yield:

p-methoxybenzyl chloride (824-94-2) → diethyl ((5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-yl)methyl)phosphonate (1381864-98-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C

2: triethylamine / dichloromethane / 0.17 h / 0 °C

3: sodium bromide / N,N-dimethyl-formamide / 0.33 h / 20 °C

4: toluene / 24 h / Reflux

With potassium carbonate; triethylamine; sodium bromide; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1007/s00044-012-0094-y

upstream raw materials:

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

p-methoxybenzyl chloride

2-(bromomethyl)-5-((4-methoxybenzyl)oxy)-4H-pyran-4-one

triethyl phosphite

Downstream raw materials:

(E)-5-(4-methoxybenzyloxy)-2-styryl-4H-pyran-4-one