3'-(3-chlorophenyl)-6',6'-dimethyl-7',8'-dihydro-6'H-spiro[imidazolidine-4,5'-isoquinoline]-2,5-dione

Base Information

Chemical Name:3'-(3-chlorophenyl)-6',6'-dimethyl-7',8'-dihydro-6'H-spiro[imidazolidine-4,5'-isoquinoline]-2,5-dione
CAS No.:1338094-23-7
Molecular Formula:C₁₉H₁₈ClN₃O₂
Molecular Weight:355.824
Hs Code.:

Synonyms:3'-(3-chlorophenyl)-6',6'-dimethyl-7',8'-dihydro-6'H-spiro[imidazolidine-4,5'-isoquinoline]-2,5-dione

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Chemical Property of 3'-(3-chlorophenyl)-6',6'-dimethyl-7',8'-dihydro-6'H-spiro[imidazolidine-4,5'-isoquinoline]-2,5-dione

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Technology Process of 3'-(3-chlorophenyl)-6',6'-dimethyl-7',8'-dihydro-6'H-spiro[imidazolidine-4,5'-isoquinoline]-2,5-dione

There total 1 articles about 3'-(3-chlorophenyl)-6',6'-dimethyl-7',8'-dihydro-6'H-spiro[imidazolidine-4,5'-isoquinoline]-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: potassium cyanide

: 1338094-22-6
3-(3-chlorophenyl)-6,6-dimethyl-7,8-dihydroisoquinolin-5(6H)-one

: 506-87-6,6721-33-1,10361-29-2
ammonium carbonate

: 1338094-23-7
3'-(3-chlorophenyl)-6',6'-dimethyl-7',8'-dihydro-6'H-spiro[imidazolidine-4,5'-isoquinoline]-2,5-dione

Guidance literature:: potassium cyanide; 3-(3-chlorophenyl)-6,6-dimethyl-7,8-dihydroisoquinolin-5(6H)-one; ammonium carbonate; With sodium hydrogensulfite; In ethanol; at 130 ℃; for 24h;

With hydrogenchloride; In ethanol; water; pH=~ 2 - ~ 3;

Reference yield: 88.4%

: 1338094-23-7
3'-(3-chlorophenyl)-6',6'-dimethyl-7',8'-dihydro-6'H-spiro[imidazolidine-4,5'-isoquinoline]-2,5-dione

: 74-88-4
methyl iodide

: 1338094-25-9
3'-(3-chlorophenyl)-1,6',6'-trimethyl-7',8'-dihydro-6'H-spiro[imidazolidine-4,5'-isoquinoline]-2,5-dione

Guidance literature:: 3'-(3-chlorophenyl)-6',6'-dimethyl-7',8'-dihydro-6'H-spiro[imidazolidine-4,5'-isoquinoline]-2,5-dione; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1338094-23-7
3'-(3-chlorophenyl)-6',6'-dimethyl-7',8'-dihydro-6'H-spiro[imidazolidine-4,5'-isoquinoline]-2,5-dione

: 2-amino-3'-(3-chlorophenyl)-1,6',6'-trimethyl-7',8'-dihydro-6'H-spiro[imidazole-4,5'-isoquinolin]-5(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C

1.2: 18 h / 20 °C

2.1: Lawessons reagent / toluene / 20 h / 110 °C / Reflux

3.1: tert.-butylhydroperoxide; ammonia / water; methanol / 48 h / 20 °C

With Lawessons reagent; tert.-butylhydroperoxide; ammonia; potassium carbonate; In methanol; water; N,N-dimethyl-formamide; toluene;