(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carbonitrile

Base Information

Chemical Name:(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carbonitrile
CAS No.:1268852-15-8
Molecular Formula:C₁₆H₂₀N₂
Molecular Weight:240.348
Hs Code.:

Synonyms:(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carbonitrile

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Chemical Property of (3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carbonitrile

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Technology Process of (3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carbonitrile

There total 1 articles about (3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 882182-35-6
2-methyl-2-(((1S)-1-phenylethyl)amino)propanenitrile

: 89892-90-0
2-(β-bromoethyl)cyclopentanone

: 1268852-15-8
(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carbonitrile

: 1268852-13-6
(3aS,6aS)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carbonitrile

Guidance literature:: In acetonitrile; for 48h; Reflux;
DOI:10.1016/j.tetasy.2010.11.017

Reference yield: 91.0%

: 1268852-15-8
(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carbonitrile

: 1268852-19-2
(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carboxylic acid amide

Guidance literature:: With sulfuric acid; In hexane; at -10 - 20 ℃; for 54h;
DOI:10.1016/j.tetasy.2010.11.017

Reference yield:

: 1268852-15-8
(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carbonitrile

: C₁₆H₂₁NO₂*ClH

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / hexane / 54 h / -10 - 20 °C

2: hydrogenchloride / water / Reflux

With hydrogenchloride; sulfuric acid; In hexane; water;
DOI:10.1016/j.tetasy.2010.11.017