(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carboxylic acid amide

Base Information

• Chemical Name: (3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carboxylic acid amide
• CAS No.: 1268852-19-2
• Molecular Formula: C₁₆H₂₂N₂O
• Molecular Weight: 258.363

Synonyms:(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carboxylic acid amide

Chemical Property of (3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carboxylic acid amide

Chemical Property:

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Technology Process of (3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carboxylic acid amide

There total 1 articles about (3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carbonitrile (1268852-15-8) → (3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carboxylic acid amide (1268852-19-2)

Guidance literature:

With sulfuric acid; In hexane; at -10 - 20 ℃; for 54h;

DOI:10.1016/j.tetasy.2010.11.017

Reference yield: 74.0%

(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carboxylic acid amide (1268852-19-2) → {[(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-yl]methyl}amine (1268852-27-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3.5h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetasy.2010.11.017

Reference yield:

(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carboxylic acid amide (1268852-19-2) → C16H21NO2*ClH

Guidance literature:

With hydrogenchloride; In water; Reflux;

DOI:10.1016/j.tetasy.2010.11.017

upstream raw materials:

(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-carbonitrile

Downstream raw materials:

(3aR,6aR)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-6a-carboxylic acid

{[(3aR,6aR)-1-[(1S)-1-phenylethyl]hexahydrocyclopenta[b]pyrrole-6a(1H)-yl]methyl}amine

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