4-tert-butoxycarbamoyl-4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-tert-butoxycarbamoyl-4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:287202-41-9
Molecular Formula:C₂₆H₃₈N₂O₇S
Molecular Weight:522.663
Hs Code.:

4-<i>tert</i>-butoxycarbamoyl-4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1-carboxylic acid <i>tert</i>-butyl ester

Synonyms:4-tert-butoxycarbamoyl-4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-tert-butoxycarbamoyl-4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-tert-butoxycarbamoyl-4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 11 articles about 4-tert-butoxycarbamoyl-4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 287202-73-7
4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

: 37477-16-0
O-(tert-butyl)hydroxylamine

: 287202-41-9
4-tert-butoxycarbamoyl-4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1016/j.bmcl.2006.05.026

Reference yield:

: 213013-98-0
4-(iodomethyl)piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 287202-41-9
4-tert-butoxycarbamoyl-4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / K₂CO₃ / dimethylformamide / 18 h / 20 °C

2: 95 percent / tetrabutylammonium oxone / CH₂Cl₂ / 20 h / 20 °C

3: 90 percent / aq. NaOH / tetrahydrofuran; methanol / 3 h / Heating

4: 48 percent / HOBT; EDC / dimethylformamide / 20 h / 20 °C

With sodium hydroxide; Oxone tetrabutylammonium salt; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.026

Reference yield:

: 287202-25-9
4-[[[4-(2-Butynyloxy)phenyl]sulfonyl]methyl]-1,4-piperidinedicarboxylic acid 1-tert-butyl 4-ethyl ester

: 287202-41-9
4-tert-butoxycarbamoyl-4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / aq. NaOH / tetrahydrofuran; methanol / 3 h / Heating

2: 48 percent / HOBT; EDC / dimethylformamide / 20 h / 20 °C

With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.026