287202-25-9

Basic information

• Product Name: 1,4-Piperidinedicarboxylic acid, 4-[[[4-(2-butynyloxy)phenyl]sulfonyl]methyl]-, 1-(1,1-dimethylethyl) 4-ethyl ester
• CAS NO: 287202-25-9
• Molecular Formula: C24H33NO7S
• Molecular Weight: 479.595
• Mol File: 287202-25-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,4-Piperidinedicarboxylic acid, 4-[[[4-(2-butynyloxy)phenyl]sulfonyl]methyl]-, 1-(1,1-dimethylethyl) 4-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Piperidinedicarboxylic acid, 4-[[[4-(2-butynyloxy)phenyl]sulfonyl]methyl]-, 1-(1,1-dimethylethyl) 4-ethyl ester(287202-25-9)
• EPA Substance Registry System: 1,4-Piperidinedicarboxylic acid, 4-[[[4-(2-butynyloxy)phenyl]sulfonyl]methyl]-, 1-(1,1-dimethylethyl) 4-ethyl ester(287202-25-9)

Safety Data

• Hazardous Substances Data: 287202-25-9(Hazardous Substances Data)

Upstream product

• 287201-95-0 4-but-2-ynyloxy-benzenethiol 
• 286459-94-7 4-but-2-ynyloxybenzenesulfonyl chloride 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1126-09-6 4-carbethoxypiperidine 
• 946857-73-4 4-(4-hydroxy-phenylsulfanylmethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 213013-98-0 4-(iodomethyl)piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 287202-23-7 1-(tert-butyl) 4-ethyl 4-({[4-(2-butynyloxy)phenyl]sulfanyl}methyl)-1,4-piperidinedicarboxylate 
• 946857-56-3 4-(4-hydroxybenzenesulfonylmethyl)piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 3355-28-0 1-Bromo-2-butyne 

Downstream Products

• 287202-33-9 4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid ethyl ester methyl ester 
• 287202-34-0 4-(4-But-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid monomethyl ester 
• 287202-73-7 4-(4-but-2-ynyloxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 
• 287202-26-0 4-[[[4-(2-Butynyloxy)phenyl]sulfonyl]methyl]-4-piperidinecarboxylic acid, ethyl ester 

Relevant articles and documents

Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors

Structure-based methods were used to design β-sulfone 3,3-piperidine hydroxamates as TACE inhibitors with the aim of improving selectivity for TACE versus MMP-13. Several compounds in this series were synthesized and evaluated in enzymatic and cell-based

Design and synthesis of butynyloxyphenyl β-sulfone piperidine hydroxamates as TACE inhibitors

A series of butynyloxyphenyl β-sulfone piperidine hydroxamate TACE inhibitors was designed and synthesized. The resulting structure-activity relationship and MMP selectivity of the series were examined. Of the compounds investigated, 17s has excellent in