(E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-pyridin-2-yl]-N-[2-oxo-3-(2-trifluoromethylphenyl)piperidin-1-yl]acrylamide

Base Information

Chemical Name:(E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-pyridin-2-yl]-N-[2-oxo-3-(2-trifluoromethylphenyl)piperidin-1-yl]acrylamide
CAS No.:1123193-84-9
Molecular Formula:C₂₅H₂₄F₃N₅O₃
Molecular Weight:499.492
Hs Code.:

Synonyms:(E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-pyridin-2-yl]-N-[2-oxo-3-(2-trifluoromethylphenyl)piperidin-1-yl]acrylamide

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Chemical Property of (E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-pyridin-2-yl]-N-[2-oxo-3-(2-trifluoromethylphenyl)piperidin-1-yl]acrylamide

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Technology Process of (E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-pyridin-2-yl]-N-[2-oxo-3-(2-trifluoromethylphenyl)piperidin-1-yl]acrylamide

There total 2 articles about (E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-pyridin-2-yl]-N-[2-oxo-3-(2-trifluoromethylphenyl)piperidin-1-yl]acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1123193-83-8
1-amino-3-[2-(trifluoromethyl)phenyl]piperidin-2-one

: (E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]acrylic acid trifluoroacetate

: 1123193-84-9
(E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-pyridin-2-yl]-N-[2-oxo-3-(2-trifluoromethylphenyl)piperidin-1-yl]acrylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield:

: 1123193-83-8
1-amino-3-[2-(trifluoromethyl)phenyl]piperidin-2-one

: 1123193-85-0
(E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]acrylic acid trifluoroacetate

: 1123193-84-9
(E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-pyridin-2-yl]-N-[2-oxo-3-(2-trifluoromethylphenyl)piperidin-1-yl]acrylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield:

: 1123193-84-9
(E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-pyridin-2-yl]-N-[2-oxo-3-(2-trifluoromethylphenyl)piperidin-1-yl]acrylamide

: 1123193-82-7
(S,E,E)-2-(2-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)vinyl)-8-(2-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

: 1123193-81-6
(+)-(8R)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

Guidance literature:: (E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-pyridin-2-yl]-N-[2-oxo-3-(2-trifluoromethylphenyl)piperidin-1-yl]acrylamide; With trichlorophosphate; at 100 ℃; for 1h;

With ammonium acetate; In acetic acid; at 150 ℃; for 2h;