(+)-(8R)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

Base Information

Chemical Name:(+)-(8R)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine
CAS No.:1123193-81-6
Molecular Formula:C₂₅H₂₃F₃N₆O
Molecular Weight:480.492
Hs Code.:

Synonyms:(+)-(8R)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

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Chemical Property of (+)-(8R)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

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Technology Process of (+)-(8R)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

There total 4 articles about (+)-(8R)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1123193-84-9
(E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-pyridin-2-yl]-N-[2-oxo-3-(2-trifluoromethylphenyl)piperidin-1-yl]acrylamide

: 1123193-82-7
(S,E,E)-2-(2-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)vinyl)-8-(2-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

: 1123193-81-6
(+)-(8R)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

Guidance literature:: (E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-pyridin-2-yl]-N-[2-oxo-3-(2-trifluoromethylphenyl)piperidin-1-yl]acrylamide; With trichlorophosphate; at 100 ℃; for 1h;

With ammonium acetate; In acetic acid; at 150 ℃; for 2h;

Reference yield:

: 1241494-92-7
(2E)-N'-{(4S)-4-cyano-4-[2-(trifluoromethyl)phenyl]butyl}-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]acrylohydrazide

: 1123193-82-7
(S,E,E)-2-(2-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)vinyl)-8-(2-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

: 1123193-81-6
(+)-(8R)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

Guidance literature:: With acetic acid; In toluene; at 20 - 70 ℃; Inert atmosphere;

Reference yield:

: 1123193-32-7
(2E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl] acrylic acid

: (3S)-2-imino-3-[2-(trifluoromethyl);phenyl]piperidin-1-amine hydrochloride

: 1123193-82-7
(S,E,E)-2-(2-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)vinyl)-8-(2-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

: 1123193-81-6
(+)-(8R)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

Guidance literature:: (2E)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl] acrylic acid; With thionyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.416667h;

(3S)-2-imino-3-[2-(trifluoromethyl);phenyl]piperidin-1-amine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 1.58333h;

With triethylamine; In N,N-dimethyl-formamide; at 20 - 70 ℃; for 1.16667h;