(6R,10S,13S)-6-(3-chloro-4-methoxybenzyl)-13-isobutyl-2,2-dimethyl-10-(2-(methylthio)ethyl)-4,8,11-trioxo-3-oxa-5,9,12-triazatetradecan-14-oic acid

Base Information

• Chemical Name: (6R,10S,13S)-6-(3-chloro-4-methoxybenzyl)-13-isobutyl-2,2-dimethyl-10-(2-(methylthio)ethyl)-4,8,11-trioxo-3-oxa-5,9,12-triazatetradecan-14-oic acid
• CAS No.: 1196466-60-0
• Molecular Formula: C₂₇H₄₂ClN₃O₇S
• Molecular Weight: 588.165
• Mol file: 1196466-60-0.mol

Synonyms:(6R,10S,13S)-6-(3-chloro-4-methoxybenzyl)-13-isobutyl-2,2-dimethyl-10-(2-(methylthio)ethyl)-4,8,11-trioxo-3-oxa-5,9,12-triazatetradecan-14-oic acid

Chemical Property of (6R,10S,13S)-6-(3-chloro-4-methoxybenzyl)-13-isobutyl-2,2-dimethyl-10-(2-(methylthio)ethyl)-4,8,11-trioxo-3-oxa-5,9,12-triazatetradecan-14-oic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R,10S,13S)-6-(3-chloro-4-methoxybenzyl)-13-isobutyl-2,2-dimethyl-10-(2-(methylthio)ethyl)-4,8,11-trioxo-3-oxa-5,9,12-triazatetradecan-14-oic acid

There total 1 articles about (6R,10S,13S)-6-(3-chloro-4-methoxybenzyl)-13-isobutyl-2,2-dimethyl-10-(2-(methylthio)ethyl)-4,8,11-trioxo-3-oxa-5,9,12-triazatetradecan-14-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

C28H44ClN3O7S → (6R,10S,13S)-6-(3-chloro-4-methoxybenzyl)-13-isobutyl-2,2-dimethyl-10-(2-(methylthio)ethyl)-4,8,11-trioxo-3-oxa-5,9,12-triazatetradecan-14-oic acid (1196466-60-0)

Guidance literature:

C₂₈H₄₄ClN₃O₇S; With water; sodium hydroxide; In methanol; at 20 ℃;

With hydrogenchloride; In water; pH=2 - 3; Cooling with ice;

DOI:10.1002/ardp.200900067

Reference yield: 50.0%

(6R,10S,13S)-6-(3-chloro-4-methoxybenzyl)-13-isobutyl-2,2-dimethyl-10-(2-(methylthio)ethyl)-4,8,11-trioxo-3-oxa-5,9,12-triazatetradecan-14-oic acid (1196466-60-0) + tert-butyl (5S,6R,2E,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoate (178977-57-6) → (6R,10S,13S)-((1E,3R,4S,6E)-8-tert-butoxy-3-methyl-8-oxo-1-phenylocta-1,6-dien-4-yl)-6-(3-chloro-4-methoxybenzyl)-13-isobutyl-2,2-dimethyl-10-(2-(methylthio)ethyl)-4,8,11-trioxo-3-oxa-5,9,12-triazatetradecan-14-oate (1196466-62-2)

Guidance literature:

(6R,10S,13S)-6-(3-chloro-4-methoxybenzyl)-13-isobutyl-2,2-dimethyl-10-(2-(methylthio)ethyl)-4,8,11-trioxo-3-oxa-5,9,12-triazatetradecan-14-oic acid; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

tert-butyl (5S,6R,2E,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoate; In dichloromethane; Inert atmosphere;

DOI:10.1002/ardp.200900067

Downstream raw materials:

(6R,10S,13S)-((1E,3R,4S,6E)-8-tert-butoxy-3-methyl-8-oxo-1-phenylocta-1,6-dien-4-yl)-6-(3-chloro-4-methoxybenzyl)-13-isobutyl-2,2-dimethyl-10-(2-(methylthio)ethyl)-4,8,11-trioxo-3-oxa-5,9,12-triazatetradecan-14-oate