9-<3-O-(tert-Butyldiphenylsilyl)-5'-O-(N-phthalimidyl)-2-deoxy-β-D-erythro-pentofuranosyl>-2-N-isobutyrylguanine

Base Information

Chemical Name:9-<3-O-(tert-Butyldiphenylsilyl)-5'-O-(N-phthalimidyl)-2-deoxy-β-D-erythro-pentofuranosyl>-2-N-isobutyrylguanine
CAS No.:166758-18-5
Molecular Formula:C₃₈H₄₀N₆O₇Si
Molecular Weight:720.857
Hs Code.:

Synonyms:9-<3-O-(tert-Butyldiphenylsilyl)-5'-O-(N-phthalimidyl)-2-deoxy-β-D-erythro-pentofuranosyl>-2-N-isobutyrylguanine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-<3-O-(tert-Butyldiphenylsilyl)-5'-O-(N-phthalimidyl)-2-deoxy-β-D-erythro-pentofuranosyl>-2-N-isobutyrylguanine

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Technology Process of 9-<3-O-(tert-Butyldiphenylsilyl)-5'-O-(N-phthalimidyl)-2-deoxy-β-D-erythro-pentofuranosyl>-2-N-isobutyrylguanine

There total 3 articles about 9-<3-O-(tert-Butyldiphenylsilyl)-5'-O-(N-phthalimidyl)-2-deoxy-β-D-erythro-pentofuranosyl>-2-N-isobutyrylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68892-41-1
5'-dimethoxytriphenylmethyl-N²-isobutyryl-2'-deoxyguanosine

: 166758-18-5
9-<3-O-(tert-Butyldiphenylsilyl)-5'-O-(N-phthalimidyl)-2-deoxy-β-D-erythro-pentofuranosyl>-2-N-isobutyrylguanine

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 16 h / Ambient temperature

2: CCl₃CO₂H / CH₂Cl₂ / 3 h / Ambient temperature

3: Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran / 16 h / Ambient temperature

With 1H-imidazole; di-isopropyl azodicarboxylate; triphenylphosphine; trichloroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a037

Reference yield:

: 166758-17-4
9-<3-O-(tert-Butyldiphenylsilyl)-5-O-(4,4'-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl>-2-N-isobutyrylguanine

: 166758-18-5
9-<3-O-(tert-Butyldiphenylsilyl)-5'-O-(N-phthalimidyl)-2-deoxy-β-D-erythro-pentofuranosyl>-2-N-isobutyrylguanine

Guidance literature:: Multi-step reaction with 2 steps

1: CCl₃CO₂H / CH₂Cl₂ / 3 h / Ambient temperature

2: Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran / 16 h / Ambient temperature

With di-isopropyl azodicarboxylate; triphenylphosphine; trichloroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00121a037

Reference yield:

: 524-38-9
N-hydroxyphthalimide

: 114745-19-6
9-<3-O-(tert-Butyldiphenylsilyl)-2-deoxy-β-D-erythro-pentofuranosyl>-2-N-isobutyrylguanine

: 9-<3-O-(tert-Butyldiphenylsilyl)-5,N³-cyclo-2'-deoxy-β-D-erythro-pentofuranosyl>-2-N-isobutyrylguanine

: 166758-18-5
9-<3-O-(tert-Butyldiphenylsilyl)-5'-O-(N-phthalimidyl)-2-deoxy-β-D-erythro-pentofuranosyl>-2-N-isobutyrylguanine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 16h; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1021/jo00121a037