Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl ester

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Chemical Name:Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl ester
CAS No.:142345-06-0
Molecular Formula:C₄₉H₅₂N₅O₉P
Molecular Weight:885.954
Hs Code.:

Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl ester

Synonyms:Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl ester

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Chemical Property of Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl ester

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Technology Process of Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl ester

There total 3 articles about Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1134-35-6
4,4'-dimethyl-2,2'-bipyridines

: 142345-06-0
Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, 0 deg C, 1 h, 2.) RT, overnight

2: Dowex 50 W / CH₂Cl₂; methanol / 48 h / Heating

3: tetrazole / acetonitrile / 1 h / Ambient temperature

With 1H-tetrazole; Dowex 50 W; lithium diisopropyl amide; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/ja00001a041

Reference yield:

: 135804-28-3
4-methyl-4'-<4-(tetrahydro-2-pyranyloxy)butyl>-2,2'-bipyridine

: 142345-06-0
Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Dowex 50 W / CH₂Cl₂; methanol / 48 h / Heating

2: tetrazole / acetonitrile / 1 h / Ambient temperature

With 1H-tetrazole; Dowex 50 W; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/ja00001a041