Technology Process of (3S,4S)-tert-butyl 4-amino-3-hydroxy-5-phenylpentanoate
There total 5 articles about (3S,4S)-tert-butyl 4-amino-3-hydroxy-5-phenylpentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
ethyl acetate;
at 20 ℃;
for 8h;
enantioselective reaction;
DOI:10.1002/psc.1254
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: thionyl chloride / -10 - 20 °C / Inert atmosphere
2.1: sodium hydrogencarbonate / tetrahydrofuran; dimethyl sulfoxide / 12 h / Reflux
3.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
4.1: sodium tetrahydroborate / methanol / 3.5 h / -22 °C
5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 8 h / 20 °C
With
sodium tetrahydroborate; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; 1,1,1,3,3,3-hexamethyl-disilazane;
In
tetrahydrofuran; methanol; hexane; dimethyl sulfoxide; ethyl acetate;
3.1: Claisen condensation / 3.2: Claisen condensation;
DOI:10.1002/psc.1254
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran; dimethyl sulfoxide / 12 h / Reflux
2.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: sodium tetrahydroborate / methanol / 3.5 h / -22 °C
4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 8 h / 20 °C
With
sodium tetrahydroborate; n-butyllithium; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; 1,1,1,3,3,3-hexamethyl-disilazane;
In
tetrahydrofuran; methanol; hexane; dimethyl sulfoxide; ethyl acetate;
2.1: Claisen condensation / 2.2: Claisen condensation;
DOI:10.1002/psc.1254
