(6S,7S)-5-(methoxycarbonyl)-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxylic acid

Base Information

Chemical Name:(6S,7S)-5-(methoxycarbonyl)-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxylic acid
CAS No.:929548-85-6
Molecular Formula:C₂₂H₂₆N₂O₅
Molecular Weight:398.459
Hs Code.:

Synonyms:(6S,7S)-5-(methoxycarbonyl)-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxylic acid

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Chemical Property of (6S,7S)-5-(methoxycarbonyl)-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxylic acid

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Technology Process of (6S,7S)-5-(methoxycarbonyl)-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxylic acid

There total 9 articles about (6S,7S)-5-(methoxycarbonyl)-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929548-84-5
7-tert-butyl 5-methyl (6S,7S)-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-5,7-dicarboxylate

: 929548-85-6
(6S,7S)-5-(methoxycarbonyl)-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm061344o

Reference yield:

: 791834-44-1
2-benzyl 3-tert-butyl (2S,3S)-1-benzyl-5-methylenepiperidine-2,3-dicarboxylate

: 929548-85-6
(6S,7S)-5-(methoxycarbonyl)-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / 28 h / 65 °C

2: 98 percent / palladium(II) acetate / diethyl ether / -20 - 20 °C

3: 98 percent / H₂ / Pd/BaSO₄ / methanol / 3 h / 20 °C

4: benzotriazol-1-yloxytris(dimethylamino)phosphonium*PF₆^(1-); 4-methylmorpholine / dimethylformamide / 2 h / 20 °C

5: 1.20 g / N,N-diisopropylethylamine / 0 - 20 °C

6: trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

With 4-methyl-morpholine; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; Pd-BaSO₄; palladium diacetate; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm061344o

Reference yield:

: 791834-42-9
1-benzyl 4-tert-butyl (2S)-2-{benzyl[2-(chloromethyl)prop-2-en-1-yl]amino}succinate

: 929548-85-6
(6S,7S)-5-(methoxycarbonyl)-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / NaI / acetone / 16 h / 20 °C

2: 72 percent / LiHMDS / tetrahydrofuran / 4 h / -78 - -30 °C

3: 93 percent / 28 h / 65 °C

4: 98 percent / palladium(II) acetate / diethyl ether / -20 - 20 °C

5: 98 percent / H₂ / Pd/BaSO₄ / methanol / 3 h / 20 °C

6: benzotriazol-1-yloxytris(dimethylamino)phosphonium*PF₆^(1-); 4-methylmorpholine / dimethylformamide / 2 h / 20 °C

7: 1.20 g / N,N-diisopropylethylamine / 0 - 20 °C

8: trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

With 4-methyl-morpholine; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; lithium hexamethyldisilazane; Pd-BaSO₄; palladium diacetate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm061344o