(4-(5-(4-(4-cyclohexylbenzyloxy)benzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)oxoacetic acid

Base Information

• Chemical Name: (4-(5-(4-(4-cyclohexylbenzyloxy)benzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)oxoacetic acid
• CAS No.: 1186633-86-2
• Molecular Formula: C₃₂H₃₀N₂O₅S
• Molecular Weight: 554.667
• Mol file: 1186633-86-2.mol

Synonyms:(4-(5-(4-(4-cyclohexylbenzyloxy)benzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)oxoacetic acid

Chemical Property of (4-(5-(4-(4-cyclohexylbenzyloxy)benzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)oxoacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(5-(4-(4-cyclohexylbenzyloxy)benzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)oxoacetic acid

There total 7 articles about (4-(5-(4-(4-cyclohexylbenzyloxy)benzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)oxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-(4-acetylphenylimino)-5-(4-(4-cyclohexylbenzyloxy)benzylidene)-3-methylthiazolidin-4-one (1186634-17-2) → (4-(5-(4-(4-cyclohexylbenzyloxy)benzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)oxoacetic acid (1186633-86-2)

Guidance literature:

With selenium(IV) oxide; In pyridine; at 110 ℃; for 3h;

Reference yield:

4-cyclohexylbenzoic acid (20029-52-1) → (4-(5-(4-(4-cyclohexylbenzyloxy)benzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)oxoacetic acid (1186633-86-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sulfuric acid / 5 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

2.2: 0 °C

3.1: thionyl chloride / dichloromethane / 0.5 h / 0 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 60 °C

5.1: piperidine / ethanol / 14 h / Reflux

6.1: selenium(IV) oxide / pyridine / 3 h / 110 °C

With piperidine; selenium(IV) oxide; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; potassium carbonate; In tetrahydrofuran; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

4-cyclohexylphenylmethyl alcohol (208259-47-6) → (4-(5-(4-(4-cyclohexylbenzyloxy)benzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)oxoacetic acid (1186633-86-2)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / dichloromethane / 0.5 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 - 60 °C

3: piperidine / ethanol / 14 h / Reflux

4: selenium(IV) oxide / pyridine / 3 h / 110 °C

With piperidine; selenium(IV) oxide; thionyl chloride; potassium carbonate; In pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-(4-acetylphenylimino)-5-(4-(4-cyclohexylbenzyloxy)benzylidene)-3-methylthiazolidin-4-one

4-cyclohexylbenzoic acid

4-(4-cyclohexylbenzyloxy)benzaldehyde

2-(4-acetylphenylimino)-3-methylthiazolidin-4-one