20029-52-1

Basic information

• Product Name: 4-CYCLOHEXYLBENZOIC ACID
• Synonyms: 4-CYCLOHEXYLBENZOIC ACID;P-CYCLOHEXYLBENZOIC ACID;Cyclohexybenzoicacid;4-CYCLOHEXYLBENZOIC ACID 98+%;Cyclohexyl benzoic acid;(4-Carboxyphenyl)cyclohexane
• CAS NO: 20029-52-1
• Molecular Formula: C₁₃H₁₆O₂
• Molecular Weight: 204.26
• EINECS: 243-472-5
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 20029-52-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 200°C
• Boiling Point: 351.1 °C at 760 mmHg
• Flash Point: 163.9 °C
• Appearance: /
• Density: 1.115 g/cm³
• Vapor Pressure: 1.56E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 1966671
• CAS DataBase Reference: 4-CYCLOHEXYLBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYCLOHEXYLBENZOIC ACID(20029-52-1)
• EPA Substance Registry System: 4-CYCLOHEXYLBENZOIC ACID(20029-52-1)

Safety Data

• Statements: 36/37/38-52/53
• Safety Statements: 26-36/37/39-61-37
• Hazardous Substances Data: 20029-52-1(Hazardous Substances Data)

Usage

Chemical Properties

Solid

InChI:InChI=1/C13H16O2/c14-13(15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h6-10H,1-5H2,(H,14,15)/p-1

Upstream product

• 18594-05-3 4-cyclohexylacetophenone 
• 27634-88-4 4-cyclohexyl-1-cyanobenzene 
• 19920-83-3 4-cyclohex-1-enyl-benzoic acid 
• 4501-36-4 1-cyclohexyl-4-methylbenzene 
• 92-92-2 biphenyl-4-carboxylic acid 
• 4463-31-4 4-cyclohexylbenzyl chloride 
• 7732-18-5 water 
• 13020-34-3 4-cyclohexyl styrene 
• 201230-82-2 carbon monoxide 
• 25109-28-8 4-bromo(cyclohexyl)benzene 
• 619-58-9 4-iodobenzoic acid 
• 256390-55-3 cyclohexylzinc chloride 
• 124-38-9 carbon dioxide 
• 110-82-7 cyclohexane 

Downstream Products

• 959141-01-6 4-cyclohexyl-benzoic acid ethyl ester 
• 121193-16-6 4-cyclohexyl-benzoyl chloride 
• 905308-71-6 3-(4-bromo-2-methyl-phenyl)-5-(4-cyclohexyl-phenyl)-[1,2,4]oxadiazole 
• 905308-51-2 4-[5-(4-cyclohexyl-phenyl)-[1,2,4]oxadiazol-3-yl]-3-methyl-benzoic acid methyl ester 
• 905308-53-4 {4-[5-(4-cyclohexyl-phenyl)-[1,2,4]oxadiazol-3-yl]-3-methyl-phenyl}-acetic acid ethyl ester 
• 911450-38-9 3-{4-[5-(4-cyclohexyl-phenyl)-[1,2,4]oxadiazol-3-yl]-3-methyl-phenyl}-propionic acid methyl ester 
• 861097-02-1 Hydroxy-bis-(3-cyclohexyl-phenyl)-(4-cyclohexyl-phenyl)-methan 
• 478370-59-1 3-(3-{[(4-Cyclohexylbenzoyl)amino]methyl}-4-methoxyphenyl)benzoic acid 
• 478370-84-2 3-(3-{[(4-Cyclohexylbenzoyl)amino]methyl}-4-methoxyphenyl)-6-methoxybenzoic acid 
• 1236360-70-5 C₄₇H₆₆N₂O₅Si 

Relevant articles and documents

Preparation method of 4-cyclohexylbenzoic acid

The invention relates to the technical field of medicine preparation, in particular to a preparation method of 4-cyclohexylbenzoic acid. The preparation method comprises the following steps: 1) preparing a Grignard reagent from 1-bromo-4-cyclohexylbenzene; 2) subjecting the Grignard reagent to reacting with carbon dioxide in an organic solvent; and 3) carrying out acidifying to obtain the 4-cyclohexylbenzoic acid. According to the preparation method of the 4-cyclohexylbenzoic acid, the raw materials are easy to obtain, cost is low, a process is stable, and the prepared 4-cyclohexylbenzoic acid is high in chemical purity; and the conditions of heating, usage of magnesium powder and the like are creatively designed, a small amount of bromocyclohexyl benzene is firstly added for initiation, and then residual bromobenzene is added under the condition of heating, so the preparation of the Grignard reagent of 1-bromo-4-cyclohexylbenzene is realized, the technical defect that an expensive catalyst or an expensive ligand needs to be adopted for preparing 4-cyclohexylbenzoic acid in the prior art is overcome, and remarkable progress is achieved.

Copper catalyzed oxygen assisted C(CNOH)-C(alkyl) bond cleavage: A facile conversion of aryl/aralkyl/vinyl ketones to aromatic acids

A novel copper-catalyzed aerobic oxidative C(NOH)-C(alkyl) bond cleavage reaction of aryl/aralkyl/vinyl ketones for the synthesis of aromatic/acrylic acids is described. A series of ketones having aryl/aralkyl/vinyl at the one end and methyl to any higher alkyl at the other end can be selectively cleaved and converted into the corresponding acids via oxime intermediates.

PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERSAS AS AGONISTS OF G- PROTEIN COUPLED RECEPTOR 43 (GPR43)

The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.