C₁₈H₃₅N₄O₅P

Base Information

• Chemical Name: C₁₈H₃₅N₄O₅P
• CAS No.: 1401808-94-3
• Molecular Formula: C₁₈H₃₅N₄O₅P
• Molecular Weight: 418.473
• Mol file: 1401808-94-3.mol

Synonyms:C₁₈H₃₅N₄O₅P

Chemical Property of C₁₈H₃₅N₄O₅P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₃₅N₄O₅P

There total 28 articles about C₁₈H₃₅N₄O₅P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl (3R,4R,5S)-4-acetamido-5-[N2,N3-bis(tert-butoxycarbonyl)guanidino]-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate → C18H35N4O5P (1401808-94-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jm3008486

Reference yield:

diethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate (950478-34-9) → C18H35N4O5P (1401808-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: mercury dichloride; triethylamine / N,N-dimethyl-formamide / 0 - 25 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

With triethylamine; trifluoroacetic acid; mercury dichloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm3008486

Reference yield:

C8H15NO4 → C18H35N4O5P (1401808-94-3)

Guidance literature:

Multi-step reaction with 15 steps

1: pyridine / 3 h / 25 °C

2: hydrogenchloride / 1,4-dioxane; toluene; water / 24 h / 0 - 25 °C

3: toluene-4-sulfonic acid / toluene / 4 h / 80 °C

4: pyridine / dichloromethane / 2 h / -15 °C

5: sodium hydride; 15-crown-5 / N,N-dimethyl-formamide / 24 h / 25 °C

6: hydrogen; palladium on activated charcoal / ethanol / 24 h / 25 °C

7: sodium ethanolate / ethanol / 5 h / 25 °C

8: diphenyl phosphoryl azide; diisopropyl-carbodiimide; triphenylphosphine / tetrahydrofuran / 48 h / 25 °C

9: hydrogenchloride / ethanol / 1 h / Reflux

10: pyridine / dichloromethane / 2 h / -15 - -10 °C

11: potassium nitrite; 18-crown-6 ether / N,N-dimethyl-formamide / 24 h / 40 °C

12: trifluorormethanesulfonic acid / dichloromethane / 24 h / 25 °C

13: hydrogen / ethanol / 16 h / 25 °C

14: mercury dichloride; triethylamine / N,N-dimethyl-formamide / 0 - 25 °C

15: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

With pyridine; hydrogenchloride; potassium nitrite; 15-crown-5; 18-crown-6 ether; trifluorormethanesulfonic acid; diphenyl phosphoryl azide; palladium on activated charcoal; hydrogen; sodium ethanolate; sodium hydride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; mercury dichloride; diisopropyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm3008486

upstream raw materials:

diethyl (3R,4R,5S)-4-acetamido-5-azido-3-hydroxy-1-cyclohexene-1-phosphonate

pentan-3-yl 2,2,2-trichloroacetimidate

diethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate

cis-(1S,2S)-1,2-dihydroxy-3-bromocyclohexa-3,5-diene

Downstream raw materials:

(3R,4R,5S)-4-acetamido-5-guanidino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonic acid

C₁₆H₃₁N₄O₅P

Refernces

• 1、 Cheng, Ting-Jen R.,Weinheimer, Steven,Tarbet, E. Bart,Jan, Jia-Tsrong,Cheng, Yih-Shyun E.,Shie, Jiun-Jie,Chen, Chun-Lin,Chen, Chih-An,Hsieh, Wei-Che,Huang, Pei-Wei,Lin, Wen-Hao,Wang, Shi-Yun,Fang, Jim-Min,Hu, Oliver Yoa-Pu,Wong, Chi-Huey. "Development of oseltamivir phosphonate congeners as anti-influenza agents". . p. 8657 - 8670. Retrieved 2013/01/15.