4-[9-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-yl]butanoic acid hydrochloride

Base Information

Chemical Name:4-[9-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-yl]butanoic acid hydrochloride
CAS No.:1165946-18-8
Molecular Formula:C₂₄H₂₆ClN₃O₅*ClH
Molecular Weight:508.401
Hs Code.:

Synonyms:4-[9-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-yl]butanoic acid hydrochloride

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Chemical Property of 4-[9-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-yl]butanoic acid hydrochloride

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Technology Process of 4-[9-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-yl]butanoic acid hydrochloride

There total 18 articles about 4-[9-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-yl]butanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1165946-75-7
4-(9-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-4-{[(1,1-dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-yl)butanoic acid

: 1165946-18-8
4-[9-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-yl]butanoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;
DOI:10.1021/jm5010336

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1165946-18-8
4-[9-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-yl]butanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C

2: triethylamine / acetonitrile / 73 h / 20 °C / Reflux

3: sodium hydroxide / ethanol; water / 2 h / 50 °C

4: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm5010336

Reference yield:

: 213767-19-2
3-chloro-4-[(1-methylethyl)oxy]benzoyl chloride

: 1165946-18-8
4-[9-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-yl]butanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetonitrile / 73 h / 20 °C / Reflux

2: sodium hydroxide / ethanol; water / 2 h / 50 °C

3: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; water; acetonitrile;
DOI:10.1021/jm5010336